"Cloveit": instructions for use, reviews and description

What is the drug "Cloveit"? Instructions for use, reviews, analogues and types of this medication will be discussed further. Also, we will talk about the side effects of this drug, its composition and therapeutic properties.

Forms and composition

In what form is the medicament "Cloveit" made? Instructions for use, the description of this drug states that it can be purchased in two different forms:

• 0.05% cream for external application in the form of a homogeneous and white mass. As the main ingredient of this drug is clobetasol propionate. It also contains the following additional substances: polysorbate 40, propylene glycol, sodium citrate, citric acid, disodium edetate, colloidal silicon dioxide, chlorocresol, cetostearyl alcohol, liquid paraffin, purified water, petrolatum white, triglycerides of octanoic and decanoic acids, glyceryl monostearate, Chemoderm 841 (flavor). The external cream "Cloveit", the instruction on which application is enclosed in a pack of cardboard, goes on sale in 25 g tubes of aluminum.

• 0.05% ointment for external application in the form of a translucent, white, soft and oily homogeneous mass. Its active element is also clobetasol propionate. In addition, the composition of this drug includes propylene glycol, white petrolatum and sorbitan sesquioleate. You can buy "Kloveit" ointment in 25 g tubes (aluminum), packed in packs of cardboard.

Therapeutic properties of the medicinal product

What features are inherent in such a drug as "Clove"? Instructions for use, reviews of specialists report that this glucocorticosteroid, which is intended for external application.

The use of the ointment or cream in question helps prevent the accumulation of neutrophils, reduce inflammatory exudation and production of lymphokines, as well as slow the migration of macrophages, reduce the intensity of granulation and infiltration.

It should also be noted that the medicine "Cloveit" shows local antipruritic, anti-inflammatory, antiexudative and anti-allergic properties.

Pharmacokinetic characteristics of the drug

Is the glucocorticoid "Cloveit" absorbed? The instruction for use states that the average concentration of its active substance in the blood of people with healthy skin is approximately 0.635 ng / ml. This value is achieved 13 hours after the first application and approximately 8.2 hours after the re-use of a 0.05% ointment in an amount of 30 g.

As for the cream, after its second application in a dose of 30 g (after 10 hours), the average concentration of clobetasol propionate in the plasma exceeds that of the ointment.

After a single application of a 0.05% ointment in an amount of 25 g, its main component reaches a peak in the blood plasma in patients with eczema and psoriasis after 3 hours. The mean concentration of clobetasol propionate is 4.65 ng / ml and 2.35 ng / ml, respectively.

It can not be said that after applying the drug to large areas of the skin, its absorption into the systemic bloodstream is possible (inflammation of the skin and damage to its integrity enhances the absorption of the drug). As a result, the patient may develop general adverse reactions.

Where is the metabolism of the glucocorticosteroid Cloveit? Instructions for use say that this drug is metabolized primarily in the liver, as well as in a small amount - in the kidneys. The absorbed drug is excreted along with the urine.

Indications for application of cream and ointment

What diseases are treated with the drug for external application of "Cloveit"? The instructions for use indicate the following indications for the use of the facility in question:

• Eczema (including its various forms);
• Psoriasis (except for extensive plaque and pustular);
• Lupus erythematosus discoid;
• Flat lichen red;
• Skin diseases that show high resistance to treatment with less active glucocorticosteroids of local use.

Prohibitions to apply cream and ointment

What kind of contraindications should a patient be warned before using a local medicine "Cloveit"? Instructions for use (the composition of the ointment and cream was described in detail above) indicates the following conditions prohibiting the application of the drug in question to the skin:

• Prurigo of the head;
• Rosacea;
• Time of breastfeeding;
• Acne vulgaris ;
• Pustular and plaque psoriasis (common);
• Cutaneous manifestations of syphilis;
• Dermatitis perioral;
• Diaper rash;
• Cancer of the skin;
• Period of pregnancy;
• Itching is genital and perianal;
• Age up to one year;
• Skin diseases of fungal, viral and bacterial origin, including herpes simplex, skin tuberculosis, smallpox, actinomycosis;
• Hypersensitivity to local medication.

Local preparation "Cloveit": instructions for use, dosage

The drug should be used only externally. Ointment or cream is applied to the affected skin areas with a small layer twice a day. The duration of a continuous course of treatment with this drug is limited to four weeks.

In resistant cases, including in the presence of hyperkeratosis, the anti-inflammatory effect of the external drug "Cloveit" should be strengthened with a bandage made of polyethylene film, applied to the area of application of the cream or ointment for the whole night. Such medical measures almost always give a positive result. It should be noted that with the change of occlusive dressings skin should be cleaned. In the future, the achieved therapeutic effect must be maintained without the use of dressings.

Side effects

Does the local drug "Cloveit" cause negative reactions? Instructions for use (analogues will be listed below) states that in some cases the drug in question contributes to the development of the following effects:

• Skin itching, burning, dry skin, steroid acne;
• Weakening of skin protection (with prolonged use);
• Atrophic changes on the skin, including its thinning, widening of blood vessels located on the surface, the appearance of striae, hypertrichosis;
• Skin pigmentation, pustular psoriasis;
• Ulceration of the mucosa of the gastrointestinal tract, gastritis, increased pressure inside the eye, symptoms of hypercorticism;
• Hypercortisy (with prolonged use of GCS), suppression of the adrenal and pituitary gland;
• Exacerbation of the symptoms of the underlying disease.

Overdose of local drug and its drug interaction

Due to the slight local absorption of ointments and cream, the development of acute overdose during use is unlikely. When chronic overdose with such drugs, as well as when they are misused, symptoms of hypercorticism may be observed in patients. The development of such a side effect requires the gradual abolition of the local remedy, but only under the close supervision of the doctor.

As for the drug interaction, at present there is no data on this.

Period of fetal feeding and bearing

Now you know what is needed for such a local tool as "Cloveit." Instructions for use, side effects of this drug have also been described above.

Can this medication be used during pregnancy? Experts argue that glucocorticosteroids intended for external application should not be used during fetal bearing in large doses and for a long time.

It should also be noted that the safety of the drug in the period of breastfeeding was not established.

Special Information

What you need to know before you use the "Cloveit" ointment (cream)? Instruction for use informs that the drug in question is not recommended for hyperkeratosis, skin lesions, as well as its dryness and thickening.

Cream "Clove" should be used only for the treatment of inflammatory skin diseases of an acute nature, including those accompanied by the development of wetness. Also, the said medicament can be used for inflammation of the skin on the scalp.

Ointment and cream are intended for short-term use. It is necessary to avoid the appointment of an external glucocorticosteroid for an extended period of time, especially for young children (because of the possible suppression of the adrenal glands).

It is forbidden to apply the drug "Cloveit" in the eye area, otherwise it can cause the development of glaucoma. The same goes for the face. It may appear atrophic changes.

When a secondary infection is attached, the patient needs to undergo antibacterial therapy.

Warm and moist conditions that were created with the application of an occlusive dressing can lead to bacterial infection. In this regard, before direct application of a new dressing, the skin should be cleaned.

Similar means

What drugs can replace the ointment or cream "Cloveit"? Experts say that there are few analogues of this medicine. They are allowed to use the following: "Clobetasol", "Powockort", "Etreex", "Dermoveit" and others.

Customer Reviews

The drug "Cloveit" is a rather popular glucocorticosteroid. Therefore, there are a lot of reviews about it. Most of them are positive. Patients claim that this remedy is good and quickly enough treats skin diseases such as eczema, psoriasis, flat lichen red, lupus discoid and others. However, he has many contraindications, as well as side effects.

One can not help saying that many consumers complain that the drug in question is contraindicated in children under one year of age. In addition, its use in children older than this age requires regular monitoring of the pediatrician (at least once a week).