Buserelin depot - description and application features

The choice of a hormonal drug should be based on careful study of the symptoms of the disease and careful identification of the risk of side effects.

The drug "Buserelin Depot" is advantageously different from others by its high efficiency and low probability of occurrence of undesirable manifestations. It is part of a group of hormonal antitumor agents.

Pharmacological action of the drug

The action of Buserelin consists of antigonadotropic, antiandrogenic, antiestrogenic, antitumor effects. Substances of the preparation "Buserelin Depot" compete with the receptors of the cells that release the gonadotropin-releasing factor (they are in the structure of the anterior lobe of the pituitary gland).

At the first stage of drug administration, a short-term increase in the concentration of LH and FSH (gonadotropic hormones) released by the pituitary gland is observed, which leads to an increase in the content of sexual homonids. After 14 to 21 days, the drug blocks the gonadotropic function through a negative feedback, which leads to a significant decrease in LH and FSH, and, consequently, a decrease in the production of sex hormones. Thus, in men the concentration of testosterone decreases, it reaches the level that is established after orchiectomy (drug castration). In women, the effect of the drug "Buserelin Depot" is to reduce the production of estradiol to the level existing in the post-mictic period.

Application of the drug "Buserelin Depot"

It is used in the treatment of prostate cancer, in some cases used to suppress the synthesis of testosterone in the testes. Also used in the treatment of breast cancer (hormone-dependent disease that is characterized by high estrogen production or appears in endometriosis). Other diseases treated with Buserelin Depot: uterine myoma, endometrial hyperplasia, IVF program in the treatment of infertility.

Contraindications and special recommendations

Hypersensitivity, orchiectomy, pregnancy, lactation. With caution take the drug for pathology of the urinary tract, metastases at the level of the vertebrae, hypertension, diabetes and diabetes. Buserelin Depot and pregnancy are incompatible concepts.

Side effects

The patient can complain of CNS ailments in the form of headaches, nervousness, insomnia, amnesia, decreased concentration, dizziness, emotional instability, sometimes depression. There may be a noise in the ears or pressure on the eyeball, visual or hearing impairment. Often there can be "tides". In the first weeks of treatment, pseudomenstruation is observed in women, then dryness in the vagina is established, demineralization of bones, a decrease in libido is possible . In men, the disease may worsen in the first 2 - 3 weeks, or there may be gynecomastia, a decrease in potency. The same can be observed: anorexia, dyspeptic disorders. Buserelin Depot and alcohol are incompatible. In patients with hypertension, pressure, heart rate may increase. From allergic reactions occurs: itching, urticaria, bronchial spasm, anaphylactic shock. Laboratory parameters change: dyslipidemia, hyperglycemia, increased transaminases and bilirubin, thrombocytopenia and leukopenia.

Principles of drug use

Intramuscular administration: Immediately after preparation of the suspension.

- with prostate cancer every 4 weeks at 4.2 mg.

- with endometriosis - administered within 4 months.

-3 months with uterine myoma.

- Infertility - 4.2 mg.

Intranasal administration:

- for treatment of female diseases, described above - entering into the nasal cavity of 900 mcg / day (one dose 3 times a day), starting from 1 - 2 days of the menstrual cycle.

- Infertility 600 mcg / day, 1 dose in the nasal cavity 4 times a day. If the blockade of the reproductive system is strongly expressed, the dose is reduced by 2 times.

Some directions:

- treatment of prostate cancer is carried out throughout life;

- the introduction of antiandrogenic drugs for 2 weeks. And within 2 weeks. The very treatment with Buserelin, prevents complications that may appear in the first weeks of treatment;

- In the first period of treatment, women may have an ovarian cyst;

- should not allow pregnancy and taking contraceptive medications before treatment with Buselenin, but the first 2 months you need to use nonhormonal protection methods;

- the drug favorably affects the treatment of endometriosis surgically, reducing the frequency of relapses.

Interaction with other drugs

Buserelin lowers the effect of hypoglycemic drugs. May lead to ovarian hyperstimulation, if used in conjunction with drugs containing sex hormones.