The drug "Antisten": analogues, instructions for use and reviews

"Antistene" (international non-proprietary name - trimetazidine) - has an antihypoxic effect. Eliminates hypoxia by restoring normal energy metabolism in cells, equalizing the volume of oxygen supplied and released. Affects the neurons and cardiomyocytes of the brain, providing them with the necessary substances.

It blocks the increased secretion of fatty acids, which are the main causes of the disruption of cellular metabolism. Relaxes the heart muscle, thereby contributing to the stabilization of myocardial contractions. Strengthens the cell membranes, preventing accumulation of potassium, calcium and sodium ions in them.

Pharmacokinetics

The active substance (trimetazidine) is rapidly and almost completely absorbed in the digestive system. The absorption of "Anti-Sten" is almost 90%. Achieving the maximum content in the blood is carried out within 2 hours. Easily overcomes the barriers between blood and tissues. Binding to plasma proteins reaches 16%. It is excreted through the kidneys (almost 60% - in its original state). The total elimination time is approximately 14 hours. In people over 65 years of age who take the drug, the elimination period is longer and reaches 24 hours.

Form of issue and composition

The drug "Antistene MB" 35 mg No. 60 (analogs can be found in the same dosage) is available in the form of biconvex, rounded tablets. Which are packaged on special polymeric containers. Each tablet of "Anti-Sten" consists of 2 layers: the inner or nucleolus has a white or yellowish tinge, on the outside there is a red shell. In one tablet of "Antistene" contains 20 mg of the basic substance - trimetazidine dihydrochloride.

The composition also includes auxiliary components, which are magnesium stearate, hypromellose, triacetin, iron oxide of yellow and red color, microcrystalline cellulose.

Instruction of "Anti-Sten"

Use inside at a daily dosage of 40-60 mg, divided into 2-3 doses. Depending on the type and severity of the disease, in each case a special course of treatment is prescribed.

Application

"Antistene" is used for:

1. Long-term therapy of cardiac ischemia: prevention of possible attacks of angina pectoris (as an independent drug or one of the components in combination therapy).
2. Therapies damage the vestibular system and the hearing organ (including dizziness, tinnitus, hearing damage).
3. Vascular damage to vision.

Side effects

A large number of patients who use this drug, there is a high tolerance.

Rarely, but there are some undesirable phenomena:

• From the gastrointestinal tract - dyspepsia, abdominal tenderness, nausea, vomiting, diarrhea disorders;
• Damage to the nervous system, manifested by cranialgia, discoordination of movements, symptoms of extrapyramidal failure, which cease with the rejection of "Anti-Steen";
• From the cardiovascular side - lowering of pressure, a feeling of palpitations, occurrence of arrhythmias;
• The blood reduces the number of platelets, agranulocytosis occurs;
• The appearance of dermatological effects in the form of allergic rash and itching of the skin.

In rare cases, toxic hepatitis occurs.

The use of "Anti-stain" is prohibited:

• In pregnant women;
• During breastfeeding;
• In children and adolescents;
• If the kidney function is impaired;
• With increased sensitivity or individual intolerance to certain components of the drug.

Use in pregnant women and during breastfeeding

Tests conducted on animals showed that "Antistain" can not have a teratogenic effect on the fetus. However, due to the lack of information about the safe treatment of "Antisten" during pregnancy, the likelihood of various deviations in fetal development can not be completely ruled out. This is why the drug does not apply to pregnant women when prescribing treatment.

It is also not determined whether Antistain penetrates breast milk. If the appointment of "Anti-Sten" is necessary, then you need to stop breastfeeding.

Not allowed for use in children.

Interaction with other medicinal products

There were no consequences of the interaction of "Anti-Steen", with its simultaneous appointment with other medicines.

At the moment, does not indicate a single case of overdose with the drug "Antistain" instructions for use. Analogues of the drug are widely used.

special instructions

"Antistene" 35 mg (analogs including) are prescribed to prevent a possible attack of angina pectoris, but it can not be used for cupping. It is not recommended to prescribe "Antistene" for the initial stage in the therapy of infarction or unstable angina.

It is not allowed simultaneous use of alcoholic beverages and treatment with "Antistene", since the active substances have the opposite nature of the effect (ethanol and trimetazidine). If one or more medications are missed, it is not allowed to use it in a higher dosage at the next application.

"Antisthene" has no effect on the reaction rate and does not cause drowsiness, so you can apply when driving.

Shelf life of "Antistena" is 36 months from the date of manufacture. Keep it in a dry, cool and inaccessible place for children. Protect from exposure to sunlight. Do not use after the expiry date, as this can significantly reduce the effectiveness or cause unwanted symptoms.

Than to replace a preparation?

In the sale are available to the drug "Antistain" analogs. Reviews about them are very positive. It is possible to use drugs similar to "Antistene" in the mechanism of action:

• Hawthorn flowers;
• "Vazomag";
• "Histochrome";
• "Dinaton";
• "Dibikora";
• "Doppelherz Cardiovital";
• "Ezofosfina lyophilizate";
• Idrinola;
• Preparations of camphor;
• "Cardionata";
• "Kudesana";
• Mexicora;
• "Meldonia";
• "Mildronata";
• Sodium adenosine triphosphate;
• Non-ion lyophilizate;
• "Orokamag";
• "Riboxin";
• "Serotonin";
• "Taufona";
• "Ubinon";
• "Phyrazira" or "Phosphadena".

"Antistene": analogues Russian

• "Angiosyl retard." It is more affordable, but as strong as Antistain (cheap analogs can be bought at any pharmacy). Has a high incidence of side effects.
• "Vero-trimetazidine" is a cheaper drug.
• "Deprenorm MB" - with its appointment there are more side effects, it is more expensive.
• "Medarum" - almost no side effects, but the drug is more expensive several times.
• "Rimecor" - has a longer action, a greater incidence of side effects, cheaper.
• "Carditrim" - causes more frequent side effects, expensive analogue.
• "Triducard" and "Trimectal" are less effective, which is why they are not recommended for use as substitutes for the drug "Antistene".

Analogues and substitutes for imported production

• "Metagard" - at appointment more often there are side effects, it is an expensive analogue
• "Predizin" - side effects occur more often.
• "Trimetaside" - has fewer side effects.
• "Precard" - a cheap, but less effective analog.
• "Trimetazidine-Teva" is a more expensive drug.

Reviews

"Antistene" (analogues also) is often used in modern therapy, therefore, and reviews about it are very diverse. The vast majority of patients responded to "Antistene" as a very effective remedy.

The medicine helped many, the patients note that their general condition improved, the sleep recovered, the pressure returned to normal. The vital potential has increased. The drug removes vertigo and noise in the head. In vascular disorders of vision, "Antistene" helps restore the function of the retina of the eyes.

Only in a small number of cases, when using the drug "Antistene" (analogues as well), during the treatment of coronary heart disease, was noted for low efficiency. Probably, it could occur as a result of the progression of the disease or in the presence of chronic heart diseases.

Of course, every person should realize that the use of one "Anti-Steen" will not affect and will not relieve the disturbances in the work of the cardiovascular or nervous systems. This drug acts only as an auxiliary and supporting agent. Sometimes even doctors have doubts about the need to use drugs of a similar nature, because often patients themselves refuse them, removing them from the therapy scheme. However, when patients comply with all the prescriptions of the treating physicians, the result and further prognosis in most cases is quite favorable.

Thus, if you apply "Antistene" (analogues as well) as the main drug in the fight against cardiac ischemia, you can get a small result. However, a greater efficacy of the drug is achieved if it is used in combination therapy as a means to improve cellular metabolism. Patients study its effects, compare with similar drugs, learn the possibility of replacing them and try to determine which one is more effective and safer.

Before using the medication, you should consult a doctor. But for familiarization in each package there is an instruction for use to the drug "Antistene". Reviews, analogs, we have been discussed in detail.