Tablets and suppositories Metronidazole

The drug is an antimicrobial and antiprotozoal agent. Metronidazole reduces the 5-nitro group, which interacts with the DNA of bacterial cells, suppresses the synthesis of nucleic acids, which leads to the death of microorganisms.

To this preparation facultative anaerobes and aerobic microorganisms are not sensitive, but it stimulates reparative processes and makes tumors more sensitive to irradiation.

The most commonly used medication in tablets, vaginal suppositories Metronidazole is used as part of a comprehensive treatment. In addition to these forms, you can find gel on the shelves of the day of external and vaginal application, a cream that is applied to the surface of the skin, and a solution for infusions.

Illnesses in which tablets, solution and suppositories are used Metronidazole:

1. Diseases of the central nervous system, including brain abscess, lung abscess, pneumonia, bacterial endocarditis, empyema, infections of joints and bones.
2. Protozoal infections (extraintestinal and intestinal amebiasis, trichomoniasis, balantidiasis, giardiasis, trichomonas urethritis and vaginitis).
3. Caused by Bacteroides spp., Clostridium spp sepsis and soft tissue infections.
4. As prevention of complications in the postoperative period after removal of the appendix, operations on the colon, female genital organs, rectal area.
5. Associated with the use of antibiotics pseudomembranous colitis.
6. It is used as a radiosensitizing agent in the treatment of tumors with radiation therapy, when tumor resistance is caused by the hypoxia of its cells.
7. Alcoholism.
8. As a topical agent for the treatment of acne, rosacea, trophic ulcers, long-term non-healing wounds, oily seborrhea and seborrheic dermatitis, anal fissures, including hemorrhoids, pressure sores, and infectious skin diseases.
9. Diseases of the gastrointestinal tract, including stomach ulcer, duodenal ulcer caused by the activity of the bacterium Helicobacter pylori, atrophic gastritis, a condition after a stomach resection for suspected cancer.

Contraindications, in which tablets, gels and suppositories of metronidazole can not be used:

1. The first trimester of pregnancy.
2. Leukopenia.
3. The period of breastfeeding.
4. Liver failure.
5. Hypersensitivity to Metronidazole.
6. Organic affection of the central nervous system.

Can I use tablets and suppositories Metronidazole in the 2nd and 3rd trimester of pregnancy? It is possible, but only if the benefit to the mother exceeds the risk for the child, because the placenta does not delay the drug, but passes through itself.

Metronidazole: composition and form of release

The most commonly used tablets. Each of them contains 0.25 g of metronidazole. In each package - 10 pieces. In one cardboard box there can be 1, 2 and 5 mesh packages.

In second place in the frequency of use - 0.5% solution for infusions, transparent, with a light green tint. In each ml of the solution contains 5 mg of Metronidazole. The solution is produced in bottles of 100 ml, packed in a cardboard box.

In addition to tablets and solution, suppositories are metronidazole suppositories (vaginal suppositories), oval with one sharp and one blunt end. Such a candle can contain 0.125, 0.25, 0.5 g of metronidazole, plus auxiliary substances, such as polyethylene oxide. One box contains 10 suppositories.

Tablets, solution Metronidazole, suppositories instructions for use:

Children who have not yet reached the age of 12 take pills three times a day based on their own weight - for each kilogram it is calculated from 5 to 16.7 mg of the drug per day. Adults and adolescents over 12 are prescribed to take the medicine three to four times a day to 250-750 mg per day.

When administered to the vagina, the dosage is 500 mg per day once before bedtime.

Intravenous infusion of 500-750 mg to three times a day for adults and children over 12.

The exact dosage is selected by the doctor. Without his advice, you can not take the drug on your own, because Metronidazole has a wide range of side effects (such as hallucinations, vomiting, diarrhea, etc.).