Streptomycin for animals: instructions for use, description and reviews

How much is and from what is shown such a veterinary drug as "Streptomycin"? The instructions for use, the price and the purpose of this medication will be discussed below.

Form, description of the veterinary product

The drug "Streptomycin sulfate" (veterinary) is a salt of an organic base, which is produced by a radiant microscopic fungus.

In the sale of this product comes in the form of a hygroscopic powder or a porous mass of white color, a bitter taste, without any smell and easily soluble in water, novocaine and saline.

"Streptomycin" for veterinary medicine is used as often as necessary. It should also be noted that it is stable in a weakly acidic medium, but it breaks well in alkali solutions (with heating) and strong acids.

Pharmacology of a medicinal product

How does the drug "Streptomycin" work for animals? Instruction for use reports that this agent has bactericidal and bacteriostatic properties against many gram-negative and gram-positive pathogenic bacteria.

The antimicrobial effectiveness of this drug is due to its ability to inhibit protein synthesis in microbial cells at the level of the ribosomes. It should also be noted that this drug has no effect on infections caused by Clostridia and other anaerobic microorganisms, fungi, plasmodia, viruses and rickettsia. In addition, some microorganisms show high resistance to streptomycin, and in breeding bacteria resistance to the antibiotic occurs within a few days. At the same time, most resistant strains develop by the end of the second month of therapy. To prevent this and eliminate the infection, you should use a large dosage of the drug, and also combine it with other antimicrobial agents.

Pharmacokinetic features of the drug

Is the drug "Streptomycin" absorbed for animals? Instructions for use say that when it is administered orally it is not absorbed and completely eliminated through the intestine.

With intramuscular injections, the active substance of this medicine is immediately absorbed into the blood, and is also found in the pleural and peritoneal cavities, bile, vitreous humor, urine and eyes.

In acute inflammatory processes in the pleural cavity, the concentration of the antibiotic can reach about 50% of the total blood level.

With the development of meningitis streptomycin is able to penetrate into the spinal canal in an amount of 10-50%.

This agent easily passes through the placenta. With normal liver function, streptomycin accumulates in high concentrations in the hepatic tubules. With the disturbed function of this organ, it enters bile in small amounts, and with cholecystitis its content in the gall bladder is approximately 85% of the blood level.

The therapeutic concentration of streptomycin in various tissues and organs is maintained for 8-13 hours. This substance is quickly removed from the body with urine.

Indications for prescribing the drug

What diseases are treated by the drug in question? What does the instruction for use of the drug say about this? "Streptomycin sulfate" is prescribed:

• With leptospirosis, tularemia, pneumonia;
• Edematous disease of pigs and erysipelas, catarrhal fever (malignant);
• Diplococcal infections, mastitis, endometritis;
• Endocarditis, meningitis, postpartum and wound sepsis;
• Actinomycosis of cattle and campylobacteriosis, as well as other diseases, the causative agents of which are highly sensitive to streptomycin.

Prohibitions to use

When should you not prescribe the drug "Streptomycin" for animals? Instructions for use, attached to the medication, indicate the following contraindications:

• High sensitivity of the animal to aminoglycoside antibiotics;
• Presence of cardiovascular and renal failure.

It should also be noted that this drug can not be combined with other aminoglycoside agents (including with "Neomycin," Kanamycin, "Monomycin," Gentamycin ") because of the possible increase in nephrotoxic effect.

Instruction for the drug "Streptomycin Sulfate" (for use in animals)

Before using the agent in question, it is dissolved in physiological saline, sterile water or 0.25-0.5% solution of novocaine. The following ratio is adhered to: 0.25 g of streptomycin and 1 ml of solvent. By the way, the glucose solution as the last one is prohibited.

More concentrated means can be too painful. The finished solution can be stored at room temperature for a week (it is better to keep it in the refrigerator compartment).

How should I use Streptomycin for animals? The instruction for use says that the ready-made solution can be administered intramuscularly, as well as locally, externally, orally, intramuscularly, intraperitoneally, intratracheally, intrauterine and intracavitary.

Intramuscular injections of animals are done deep into the muscle. This therapy is carried out for 4-7 days. The medication is administered twice a day at intervals of 12 hours in the following dosages:

• Cattle small - 10 mg / kg for adults and 20 mg / kg for young animals;
• Horses - 5 mg / kg adult animals and 10 mg / kg young;
• Large cattle - 5 mg / kg for adults and 10 mg / kg for young;
• Dogs, pigs - 10 mg / kg for adults and 20 mg / kg for young animals;
• Chicken - 30 mg / kg for adults and 40 mg / kg for young.

With leptospirosis, the drug "Streptomycin" is administered for 4-10 days at a dosage of 25 mg / kg. In more severe cases, this amount is increased.

It should also be noted that, if necessary, this medication is combined with "Polymyxin", "Penicillin" and sulfonamide drugs. This combination of drugs causes synergism of action, and also prevents the emergence of resistant pathogens to streptomycin.

Adverse events

Now you know what the drug "Streptomycin Sulfate" is for. The instructions for use for animals have also been described above.

With intramuscular injections, a rapidly developing allergy can manifest itself in cattle , which is a threat to the health and life of the animal. The occurrence of such complications is associated with the characteristics of his organism and does not depend on the dosage of the antibiotic used.

Also, various complications can develop after the first administration of the drug substance, which is most often caused by sensitization of the animal during repeated courses of therapy.

When treating this drug in livestock may be observed toxic reactions, diarrhea, tachycardia, dermatitis, deafness and impaired coordination of motion.

Cost and Feedback

The cost of the drug in question (1 g bottle) is about 18 rubles.

Some experts do not advise mixing "Streptomycin Sulfate" and "Penicillin" in one syringe. However, other veterinarians successfully apply this combination in the treatment of livestock.

People who are in contact with a veterinary drug for a long time argue that such contact often caused them to develop dermatitis.

According to experts, the slaughter of animals that were administered "Streptomycin" is allowed only one week after the last use of the drug. The meat of animals killed before the deadline should be used for the production of flour.

As for milk, for food purposes it can be used only after two days after the last administration of the drug.