"Prosulfin" preparation: instructions for use, reviews and analogues

Medication "Prosulfin" instruction for use is positioned as a powerful antipsychotic agent, which is used in the therapy of various disorders of the nervous system and other diseases. More details about the above drug read on.

Brief description of the preparation

This medicine belongs to the group of substituted benzamines. In another way, it can be said that the drug "Prosulfin" is a typical neuroleptic. Experts' feedback indicates that its action is aimed at blocking dopamine receptors (D2 and D3). Thanks to this, the above drug produces an antipsychotic therapeutic effect.

50 or 200 mg of sulpiride substance contains one tablet of the preparation "Prosulfin".

Of course, in some cases, side effects when taking this medication are manifested. Therefore, the patient during the course of therapy with the above antipsychotic should be under strict supervision of a doctor.

This medicine has several forms. It is available in tablet form, as well as in the form of capsules, a solution for intramuscular injection and fluid for oral administration.

The drug should be stored at normal room temperature, but not above 25 degrees Celsius. The place should be well protected from light and moisture. About two years is the expiration date of the preparation "Prosulfin". Analogues to find it is not difficult. The drug market offers a wide range of substitutes for the above medication.

The pharmacological effect of the above therapeutic agent

The drug "Prosulfin", a photo of which is provided below, is an antipsychotic, that is, a neuroleptic. The substance of sulpiride, due to the blocking of dopamine receptors in the tuberoinfibdibular region, significantly increases the level of prolactin. It should be noted that in the range of 60-80%, the degree of blocking of dopamine receptors varies.

The latter are characterized by a fairly high similarity with benzamides, which have a characteristic feature, such as a bifacial effect on the neurotransmitter dopamine system. In addition, they block the increase in the synthesis of dopamine in the synaptic region, that is, antagonists of auto-receptors of presynaptic D2 D3.

It should be noted that the above drug is characterized by moderate neuroleptic activity. The latter is combined with the timoanaleptic and stimulating action of this drug.

The above drug has the following pharmacological action:

• Antiemetic (dopamine receptors blockade the trigger zone of the vomiting center);
• Antidepressant;
• Antipsychotic.

Sulpiride shows antidepressant effect in doses up to 600 mg. Above this rate, the antipsychotic effect of this drug on the body is already observed.

In addition, the preparation "Prosulfin", the instruction indicates this, produces a selective effect on the hypothalamus with symptoms of peptic ulcer and gastroduodenitis. At the same time, high excitation of the nervous system sympathetic centers is suppressed, gastric blood supply improves, proliferation of granulation tissue, mucus secretion processes in the stomach, regenerated epithelium is formed, proliferation of capillaries in tissues improves.

Who should take this medicine?

What are the "Prosulfin" medications for indications? For medicinal purposes the above medicine is used for such diseases:

• Psychosomatic illnesses;
• Stress ulcers of the digestive tract;
• Symptomatic ulcers;
• Gastroduodenitis;
• A stomach ulcer;
• Irritable bowel syndrome (thick);
• Drug ulcers;
• Nonspecific colitis ulcerative;
• Depression of different etymologies;
• Neuroses;
• Reactive depression;
• Dysphoric disorders;
• schizophrenia;
• Chronic mental disorders ;
• migraine;
• Acute mental disorders;
• Dizziness of various etymologies (vestibular neuritis, vertebrobasilar insufficiency, Meniere's disease, otitis media).

The drug "Prosulfin" instruction for use suggests the use to treat violations of behavioral reactions and psychoses in young patients, that is, in children. These are diseases such as self-mutilation, agitation, stereotyping. Also, the "Prosulfin" medication instruction is strongly recommended for use as part of the course of therapy of childhood autism. This tool is used to treat small patients aged 6 years.

Contraindications to the use of the above medicine

The preparation "Prosulfin" is not recommended for use if the patient has the following symptoms:

• Hypersensitivity to the components of the drug;
• Hyperprolactinemia;
• Prolactin-dependent tumors (breast cancer, prolactinoma of the pituitary gland);
• Affective disorders;
• Acute alcohol poisoning that contains alcohol;
• aggressive behavior;
• Pheochromocytoma;
• Acute poisoning with drugs or medicinal sleeping pills;
• Manic psychosis.

All these conditions are strict contraindications. Also, the use of the "Prosulfin" medication is forbidden for women who breastfeed their babies, children under 18 (for 200 mg pills), small patients under 6 years (for pills 50 mg).

In addition, it should be remembered that with the congenital deficiency of lactose, malabsorption of glucose-galactose, lactose intolerance, it is also undesirable to use the preparation "Prosulfin". Contraindications to the use of the above medicinal product also apply to pregnant women. Use it for such patients is allowed only if the expected benefit from this medication will be much higher than the potential risk from it to the fetus.

Side effects

When taking the drug "Prosulfin" (the instruction indicates this), there may be some side effects:

• On the part of the endocrine system - galactorrhea, dysmenorrhea, amenorrhea, frigidity, impotence;
• From the side of nerves - sedative effect, tremor, dizziness, early dyskinesia, extrapyramidal syndrome, drowsiness, akinesia with muscle hypertonia, akathisia, motor excitement;
• Increased enzyme activity (from the digestive side);
• Hemolytic anemia, leukocytosis, aplastic anemia, granulocytosis, thrombocytopenic purpura occur with increasing doses of the preparation "Prosulfin" (action on the part of the lymph and blood system);
• Tachycardia, orthostatic hypotension, a decrease or increase in arterial pressure, prolongation of the QT interval, in some cases development of such a dangerous disease as torsade des pointes (from the heart and his system).

Other side effects also cause this medication. The preparation "Prosulfin" (the instruction, the doctors' reviews and the patient's responses testify to this) can provoke such unpleasant phenomena as tardive dyskinesia, which is characterized by involuntary rhythmic movements of the face or tongue (with prolonged therapeutic course by neuroleptics of all groups), hyperthermia. Specialists warn that in the latter case it is especially important to cancel the above remedy in time, as a rise in temperature can be a sign of the development of such a dangerous disease as malignant neuroleptic syndrome.

Increased body weight, increased sweating, skin rash and itching - all these side effects can also cause the drug "Prosulfin". Instruction, expert reviews recommend in such cases to stop taking the above medication and immediately contact the doctor for medical help and advice.

Use during the pregnancy of the above medicinal product

The teratogenic effect of the drug was not detected as a result of animal experiments. Some women who used this medication during their pregnancy also did not observe the above effect. But these patients took strictly low doses of the "Prosulfin". Instructions for use, expert reviews do not have specific information on the use of a higher amount of a substance such as sulpiride. There is also no evidence of the effect of the above drug on fetal brain development.

As a precautionary measure, experts do not advise using this medicine for women in the situation. Although in some cases, the treatment with the above-mentioned drug is still acceptable for patients, which is expected by the baby, but strictly in minimum doses.

Specialists note that if the mother has been receiving therapy with neuroleptics for a long period of time, neonatal crumbs have had problems with the functioning of the digestive tract (for example, bloating).

If a woman uses a medicine in the period before giving birth, then control over her body and development of the fetus by the doctor is mandatory.

Also, remember that the drug "Prosulfin" penetrates into breast milk. Instructions for use, expert reviews do not recommend taking it during lactation.

How to take the drug "Prosulfin"?

The instruction instructs patients to use the above antipsychotic every 8 hours on a single pill. It is not recommended to take the medicine after 4 pm, as its activity at this time is very high. It should be noted that it is used regardless of the intake of food and washed down with a sufficient amount of liquid preparation "Prosulfin".

Tablets that contain 200 mg of sulpiride are taken with symptoms of acute schizophrenia, delirious psychosis and depression. The drug can be taken in several ways. The maximum daily dose is 100 mg, that is, about 5 pills.

Tablets, which include 50 mg of sulpiride, the instruction suggests taking if the patient shows signs of neurosis, anxiety. Within 4 weeks, such patients should consume at least one and a maximum of 3 tablets a day.

Also, such pills can be taken in children with severe behavioral disorders. The age of such patients must necessarily be above 6 years. The maximum daily dose for patients in this category is from 5 to 10 mg per 10 kg of the body weight of the child.

Overdose

The instruction indicates that information on the overdose of sulpiride is limited. The following symptoms can be observed in this condition in the patient:

• Protrusion of the tongue;
• Dyskinesia with spasmodic torticollis;
• Blurred vision;
• Dry mouth;
• Possibly development of the NSA;
• Extrapyramidal symptoms;
• Increased sweating;
• nausea;
• Sedative effect;
• Gynecomastia;
• Parkinsonism;
• Increased arterial pressure.

Treatment of the above condition of the patient is carried out as follows:

• The stomach of the patient is washed;
• Assigned activated carbon;
• Systematic therapy is used.

If necessary, in particularly severe cases, the doctor may prescribe additional manipulations, such as forced diuresis with infusion of alkaline solutions or monitoring of vital body functions.

It should be noted that this drug is partially excreted during hemodialysis.

Some categories of patients should take special precautions when using the drug "Prosulfin". This applies primarily to women with irregular menstruation, patients with severe hypotension and hypertension.

It is also important to conduct a preliminary electrophysiological and clinical examination in patients with epilepsy. It should be remembered that the preparation "Prosulfin" lowers the threshold of convulsive activity.

In addition, when driving vehicles should be very careful during the treatment with the above medication. It is also important to limit occupations that require rapid psychomotor reactions and increased concentration of attention.

Interaction with other medicinal products

The instruction strictly does not recommend the inclusion of the above drug in complex therapy with levodopa. The two active substances are antagonists. If a patient who suffers from Parkinson's disease takes levodopa, the doctor should choose a remedy that has a minimal extrapyramidal effect.

Arrhythmia such as torsades de pointes can cause a combination of the preparation "Prosulfin" with:

• Antiarrhythmic drugs that belong to the class Ia (drugs "Dizopiramid", "Quinidine");
• Preparations Pimozid, Haloperidol, Thioridazine, Cisapride, Pentamidine, imipramine antidepressants;
• Antiarrhythmic drugs that are included in the 3rd class (Sotalol, Kakamiodaron);
• Drugs that cause symptoms of a disease such as bradycardia (beta-blockers of calcium channels);
• Drugs that contribute to the appearance of signs of hypokalemia (laxatives that are stimulating, hypokalemic diuretics, tetracosactides, glucocorticoids);
• Antiparkinsonian antagonists: apomorphine, amantadine, lisurid, ropinirole, entacapone, bromocriptine, selegiline, pramipexole, piribedil);
• Neuroleptics, which have the ability to cause symptoms of pirouette tachycardia (Chlorpromazine, Amisulpride, Tsiammamizin, Pimozid, Droperidol, Levomepromazin, Tiaprid, Sertindol, Veralipride, Sulpiride). ;
• Drugs that contain lithium (the latter significantly increases the risk of extrapyramidal disorders).

Also, in no case should the preparation "Prosulfin" be consumed with alcohol. The latter potentiates the sedative effect of neuroleptics.

In addition, if you take the above medication in combination with centrally stimulating substances (antiasthmatic drugs, anorectics), then the patient may have symptoms of severe agitation, nervousness, anxiety, anxiety.

It should be remembered that this antipsychotic drug lowers the effectiveness level of ropinirole.

Substitutes of the therapeutic agent "Prosulfin"

Analogs of the above antipsychotic drug:

• "Betamak T100";
• "Vero-Sulpirid";
• "Betamax T50";
• "Deport";
• "Betamax";
• "Dogmatist";
• "Betamaks T200";
• "Sulpiride";
• "Egonil";
• "Sulpiril";
• "Eglek".

But to replace without prior consultation with the doctor does not recommend "Prosulfin" instructions for use. His analogs also have their own individual side effects. They can cause great harm to the patient's health.

Responses to the medical device "Prosulfin"

Reviews about the above remedy are mostly positive. A lot of patients take it when depressed. They argue that this remedy helps to eliminate the symptoms of this disease by almost 100%.

In addition, there are a lot of patient responses that, in diseases such as schizophrenia, enterocolitis, colitis, psychosis, enteritis, peptic ulcer, irritable bowel syndrome, took the preparation "Prosulfin". Their testimonials indicate that in all cases this remedy produces an incredible curative effect. In addition, patients note that side effects are very rare.

The drug considered above has serious side effects, so it is strictly forbidden to use it without first consulting a doctor.