"Cleavas": instructions for use, reviews

The increase in cholesterol causes serious fear, especially if a person suffers from cardiovascular diseases. The drug "Cleavas", the instruction on which describes in all details the rules for taking the medicine, helps to lower cholesterol to the norm and to stabilize the patient's condition in the future.

Composition and form of release

The drug "Cleavas" (instructions for use attached to the drug) is available in tablets coated with a white coating. The pills are enclosed in an aluminum blister for ten pieces. In a cardboard box there can be one or three blisters.

Tablets are available in a dose of 10 mg and 20 mg. Active substance is rosuvastatin.

Pharmacology

Rosuvastatin belongs to selective inhibitors of HMG-CoA reductase, an enzyme. Converts HMG-CoA to mevalonate, the precursor of cholesterol. The main zone of rosuvastatin is the liver. It is here that cholesterol is combined and LDL catabolism.

The therapeutic effect is noticeable during the first week of taking the drug, after 14 days the positive result is 90%. The greatest effect can be achieved by taking the drug continuously throughout the month.

Taking rosuvastatin gives the best result both in therapy of patients with hypercholesterolemia and without hypertriglyceridemia. The effect occurs regardless of gender, age or race. A positive result is observed in people with diabetes and suffering from family hypercholesterolemia.

Additivity is observed in combination with fenofibrate in the presence of TG and with nicotinic acid in relation to the content of HDL cholesterol.

Indications

Use of "Cleavas" (instructions for use informs about contraindications, which should be taken into account before taking medication) for adults is indicated for hypercholesterolemia. Assign a remedy in the initial stage of hypercholesterolemia and with a mixed type of dyslipidemia. Use pills as an additional therapy to a diet, when therapeutic nutrition, physical education and weight loss are not enough.

Assign the drug for homozygous familial hypercholesterolemia. They are supplemented by a diet and the use of other lipid-lowering medications. The drug is prescribed and when the application of the above methods is not possible.

Recommend a drug to patients with cardiovascular disorders, with the likelihood of atherosclerotic diseases of a cardiovascular nature. These risk factors include high blood pressure, elderly age, decreased cholesterol, increased C-reactive protein, a predisposition to the development of coronary heart disease and smoking.

The drug is often used in the therapy of atherosclerosis. In this situation, he slows down the development of the disease in people who are prescribed lipid-lowering therapy.
"Cleavas" can be used to treat children between the ages of ten and seventeen. The boys should have stage II of the disease and higher on the Tener scale, girls can take the drug no earlier than one year after the start of the first menstruation. Here the drug is prescribed for the therapy of primary hypercholesterolemia, as well as for the diagnosis of "mixed dyslipidemia" if the disease has developed due to heterozygous familial hypercholesterolemia. The drug is used in conjunction with a therapeutic diet and along with non-drug treatment methods.

Contraindications

Tablets "Cleavas" (instructions for use before the drug should be studied), despite the high therapeutic effect, can not be used with increased sensitivity to the active substance of the drug - rosuvastatin, as well as to any auxiliary component in their composition. The prohibition to use is liver disease in their active phase, severe malfunctioning of the kidneys and myopathy. Do not combine medication with cyclosporine. Doctors do not prescribe pills if a woman is pregnant or nursing a baby. To the ladies of childbearing age, when using the medication, it is recommended to use adequate contraceptives.

Dosage of 40 mg should not be given to people with a predisposition to progressing myopathy / rhabdomyolysis. This includes diseases of the renal system of moderate severity, hypothyroidism, hereditary muscle diseases and myotoxicity in the history, passion for alcoholic beverages. Do not take such a dose in situations that help increase the level of active substance in the blood. You can not take this amount of the drug to people of the Mongoloid race.

Cleavas: instructions for use

20 mg (10 mg) of the active substance rosuvastatin is contained in each tablet. The pills are drunk regardless of the time of day and eating. They can not be chewed, but should be swallowed whole, washed down with a lot of water.

Therapy for hypercholesterolemia starts with small doses, 5-10 mg once a day. This amount is suitable both for individuals who have not previously used statins, and for patients who previously used inhibitors of HMG-CoA reductase. When calculating the primary dose rely on the natural level of cholesterol in the blood and the possible risk of cardiovascular disease, the likelihood of side effects. The dose can be increased after four weeks.

Given that with a daily dose of 40 mg, adverse events develop more often than with a smaller amount of the drug, it is only necessary to raise the dose to 40 mg for patients suffering from severe hypercholesterolemia and having a high risk of developing cardiovascular ailments. If the desired result is not obtained at a dose of 20 mg, then when the dosage is increased to 40 mg the patient should be under the supervision of a doctor.

To prevent cardiovascular failure, the daily dose of the drug is 20 mg. For the elderly over 70, the daily allowance should not exceed 5 mg.

For children and adolescents with heterozygous familial hypercholesterolemia, the drug is prescribed 5-20 mg once a day, the dose should be titrated.

For people with moderate renal dysfunction, the initial dosage is 5 ml. The drug in the amount of 40 mg is contraindicated. You can not use "Cleans" (the manual describes this situation in more detail) to patients with severe diseases of the renal system.

Tablets are contraindicated for persons suffering from active kidney diseases. In patients with severe diseases of the renal system, an increase in rosuvastatin may occur. In this case, the therapeutic dose does not exceed 10 mg.

In individuals of the Mongoloid race, there was an increase in systemic exposure to rosuvastatin, so treatment with 5 mg is started. The therapeutic dose of 40 mg is strictly contraindicated. The maximum daily allowance is 20 mg.

People prone to progressing to myopathy start therapy with 5 mg, and a dose of 40 mg to many of them is prohibited. The maximum amount of substance taken per day is 20 mg.

Side effects

Many patients are interested in: Does the negative reaction of the body "Cleavas" (tablets)? The instruction describes in detail all the features of the use of the drug. According to the annotation, only light and transient side effects were recorded. Nausea, dizziness, myalgia, constipation, diarrhea, asthenia (at high doses), cough, myopathy were observed.

From time to time, the patients had itching, hives, rashes on the skin. There are cases of proteinuria with tubular origin. There was a change in the protein in the urine, which was expressed in an increase in the level of hepatic transaminases. Mild depression, insomnia, nightmares and sleep disturbances, sexual dysfunction were recorded.

During treatment, people were disturbed by reactions caused by a special sensitivity to the drug (sometimes there was angioedema). Some patients were diagnosed with pancreatitis and myopathy (including myositis). Rhabdomyolysis was recorded, its frequency in some cases depended on increasing the dose.

Very rarely there was polyneuropathy, loss of memory. In isolated cases, jaundice and hepatitis were recorded. Sometimes there was Stevens-Johnson syndrome, arthralgia, hematuria, puffiness.

Overdose

Strongly recommends to follow the recommended dosage when taking the "Cleavas" tablets instruction. The reviews state that it is an effective and very affordable drug. Gives a persistent lasting result. For each patient an individual dose is calculated, and if it is not observed, an overdose may occur. There is no special treatment here. Therapy is performed according to the symptoms. At this time, you need to carefully monitor the liver and the level of CK. Hemodialysis does not give the desired effect.

Storage conditions

The medicine "Cleavas" (instructions for treatment with this drug must be observed) should be stored in the original package at a temperature regime not exceeding +25 ° C in a place inaccessible to children. The medication is suitable for two years from the date of manufacture.

Analogues of "Cleavas"

The drug "Cleavas" is not common in Russia, therefore, despite its effectiveness, people have to look for a replacement.

Analogues with the same active ingredient (rosuvastatin) include the following medicines: Krestor, Mertenil, Redistatin, Roviks, Rozav, Rosart, Rosvator, Rosuvastatin KRKA "," Rosuvastatin Teva "," Rosukard "," Rosulip "," Rosusta "," Romantis "," Rosukor "," Rifast "," Fastong ".

These and other drugs can completely replace "Cleavas". The difference between them is the price, the manufacturer and the concentration of the active substance.

Patient Reviews

Warns that it is important to comply with all prescriptions of the doctor when taking the "Cleavas" tablets instructions for use. Reviews about this product are extremely positive. Patients say that during the first two weeks the drug stabilizes the patient's condition and normalizes cholesterol. It is cheap and the patients who took it are happy with the result.

Warns that it is important to comply with all the prescription of the doctor when taking the "Cleavas" tablets, instructions for use. Reviews about this product are extremely positive. Patients say that during the first two weeks the drug stabilizes the patient's condition and normalizes cholesterol. It is worth the drug is cheap, and the patients who took it, are satisfied with the result.

Despite this, some people who took large doses indicated side effects. They were disturbed by sleep, nightmares arose, depression arose. However, the doctors recommended not to stop treatment and drink the medicine for at least a month. After the course of treatment, the patients normalized with cholesterol, and the side effects disappeared.