Candles "Proktoglivenol": reviews, instructions for use, analogues

Do candles help "Proctaglivenol"? Reviews about the effectiveness of this medication will be presented below. Also you will learn about how this drug works, when it is prescribed, how much it costs and whether it has analogues.

Packaging, composition

Candles "Proctoglivenol", the instruction for use of which is contained in a cardboard pack, go on sale in blisters for 5 pieces. They are white oblong suppositories for rectal administration and include in their composition such active substances as tribenozide and lidocaine. Also, this preparation contains auxiliary components in the form of Witepsol E85 and Witepsol W35.

One can not help saying that another form of this drug can be found on the market. "Proctoglivenol" - ointment is white, homogeneous, opaque and has a specific odor. It is available in 30 g tuba and contains similar active ingredients.

Basic properties

The medicinal preparation "Proctoglivenol", the price of which will be indicated below, is intended for local treatment of hemorrhoids. It contains two active ingredients - lidocaine and tribenozide. Due to their presence, the medication is able to provide venotonic, local anesthetic and anti-inflammatory action. It also improves microcirculation, reduces pain and intensity of the inflammatory process.

When candles are used in recommended dosages, there is a decrease in venous stasis, a decrease in vascular permeability, and the removal of such unpleasant signs of hemorrhoids as pain and itching in the rectum and anus.

Operating principle

Therapeutic effects and the mechanism of action of the medicament in question are due to the pharmacological features of the active substances that make up its composition.

So how do Candlesticks work? Instructions for use say that tribenozide is a synthetic substance belonging to the class of glucofuranosides. The mechanism of its action has not been studied to the end. However, experts suggest that it is related to the ability of tribenoside to depress the activity of endogenous amines, such as histamine, bradykinin and serotonin, in a depressing manner.

One can not help saying that tribenozide is an antagonist of humoral factors that promote the development of edema, vasodilation, increased permeability and inflammation of blood vessels.

In the process of research, it was noted that the drug "Proctoglyenol" (ointment and suppositories) does not affect the activity of endogenous vasoconstrictors, including norepinephrine and epinephrine. This drug eliminates stagnant phenomena in the veins, as well as increases their tone and helps reduce the (pathologically) permeability of blood vessels.

Representing an antagonist of inflammatory mediators, tribenozide during application reduces the intensity of the inflammatory process, has anti-edematous and analgesic effect. It should also be noted that the substance in question reduces the ability of platelets to adhere.

What is the role of lidocaine in the preparation "Proctaglyvenol" (the price of this drug is available to everyone)? This element is a local anesthetic, which refers to acetanilide derivatives.

The principle of action of the said agent is based on its ability to block sodium channels, as a result of which cell membranes are stabilized.

Specialists report that lidocaine well inhibits generation, as well as impulses in nerve fibers. In this case, its suppressing effect on the conduction of both painful impulses and impulses of other modalities is observed.

In the process of topical application, the substance in question has no effect on the myocardium.

Kinetic characteristics of the preparation

Are the "Proctoglivenol" candles absorbed? The reviews state that with the administration of this drug rectally, the bioavailability of tribenozide is approximately 30% of that when using oral forms with the same active substance.

The peak plasma concentration of tribenoside with rectal administration is about 1 μg / ml. This value is reached after 2 hours after the introduction of candles.

As for the cream "Proctaglivenol", when it is used in the systemic blood stream, approximately 5-20% of tribenoside is supplied. The metabolism of tribenozide occurs in the liver, and it is excreted as metabolites mainly by the kidneys.

According to the attached instructions, lidocaine is fairly well absorbed when applying cream to mucous membranes. It should be noted that after application to the intact skin, the absorption of this substance is negligible.

After rectal administration of the suppository, the bioavailability of lidocaine is approximately 50%, and the peak of its plasma concentration is about 0.7 μg / ml (achieved within two hours).

Indications

What are the "Proctoglivenol" candles for? The reviews report that this remedy is actively used for conservative treatment of external and internal hemorrhoids in people with moderate weight and a mild course of the disease.

Also, the drug in question can be used in the treatment of patients with severe hemorrhoids, if for any reason there is no possibility of an operative intervention.

Contraindications

Do the candles Proctoglivenol have contraindications? Experts say that there are not enough bans to use this drug. It is not assigned only in the following cases:

• In the first trimester of pregnancy;
• At high sensitivity to elements of a medicine;
• Children (due to lack of reliable data on the safety and efficacy of the drug).

How should I use candles from the hemorrhoids "Proctoglivenol"?

Patients' reviews report that this medication is effective only if you strictly follow all the doctor's recommendations.

The drug in question is used rectally. Before entering the anal pass, wash hands thoroughly.

The duration of the course of therapy and the dosage of the drug is determined only by the attending physician, individually.

Usually adults with the development of acute hemorrhoids medication prescribed 1 suppository two times a day (or 1 application ointment). Treatment procedures are carried out in the morning and in the evening, until the acute symptoms disappear completely.

As soon as the clinical picture improves, as well as all the signs of the disease disappear, they switch to applying 1 suppository or 1 application of the ointment once a day.

Adult patients with the development of internal hemorrhoids, this drug is also prescribed in the form of a cream or suppository according to the standard scheme. In this case, it is recommended to administer the ointment directly into the rectum using a special applicator.

Actions of a negative nature

The drug from hemorrhoids "Proctoglivenol" is well tolerated by patients. Sometimes, against the background of its use in humans, there were local allergic reactions, including itching. Also in isolated cases, when using the medication, patients complained of a burning sensation in the anus.

The drug "Proctoglivenol" (candles) during breastfeeding and during pregnancy

According to the attached instructions, the medication in question can be used during lactation. However, this should only be done according to the doctor's prescription.

Can I use Proctoglivenol (candles) during pregnancy? This tool is not recommended for use in the first three months of bearing the fetus. In the second and third trimester, it can be prescribed, but only if the benefit to the mother exceeds the potential risk for the child.

Cases of overdose

To date, no reports of an overdose have been received by the agent in question.

If the drug was accidentally swallowed by the patient, then an urgent gastric lavage is carried out, and also the administration of enterosorbents is prescribed. If required, then perform symptomatic therapy.

The cost of a medicinal product, its analogs

How much is and how can I replace the medication "Proctoglivenol" (candles)? Analogues, the price of this drug will be presented right now.

If for some reason or other the remedy is not suitable for you, you can use the following medicines for hemorrhoids instead: "Anuzol", "Bezornil", "Relief Pro", "Betiol", "Proctozan Neo", "Pilex", "Proctosidil" "," Proctan "," Relief "," Hemorron "," Aurobin ", extract of Belladonna," Proctosan ".

As for the price, the candles and cream "Proctoglivenol" it can vary. As a rule, suppositories cost about 400 rubles, and an ointment of about 550 rubles.

Reviews about the medicinal product (suppositories and rectal ointment)

Reviews of rectal suppositories are mostly positive. Patients suffering from inflammation of hemorrhoids, argue that in just a few days this drug can remove all the unpleasant sensations of itching, burning and pain associated with this disease. Also, the medication is good for cracks in the anus and almost never causes allergic reactions.

One can not help saying that most patients prefer to use the ointment Proctoglivenol. Their choice is explained by the fact that rectal suppositories end much faster, and the ointment can be used for a very long time. At the same time, it quickly and reliably removes all the uncomfortable symptoms accompanying the inflammation of the hemorrhoids, and greatly accelerates the healing process.