Antibiotic 'Cefotaxime'. Instructions for use, contraindications, side effects

The name of the drug "Cefotaxime" absolutely coincides with its International patented name. The drug belongs to the clinical and pharmacological group of third generation cephalosporins. The pronounced bactericidal action of the drug is due to the inhibitory effect of the drug on the bacterial cell wall . There is a wide range of the drug "Cefotaxime". Instructions for use indicate its high activity against a large group of Gram-negative bacteria, some of which are resistant to other antibiotics.

In view of the fact that the drug is administered parenterally, the form of the drug "Cefotaxime" is the powder from which the injection solution is made.

There are good pharmacokinetic properties of the antibiotic "Cefotaxime". Instructions for use indicate its fairly rapid distribution in the tissues of the body, especially high concentrations of the drug reaches in the cerebrospinal fluid. The drug is excreted completely during the day, most of it leaves the body with urine (up to 60%).

The drug "Cefotaxime". Indications for use

The medication "Cefotaxime" is recommended for patients who are diagnosed with infectious and inflammatory diseases caused by microorganisms that are sensitive to the drug. Among such pathologies are, in the first place, infections of the central nervous system, for example, meningitis. There is a high effectiveness of the drug in the treatment of ENT organs and respiratory tract infections.

The list of indications for use is continued by the following diseases:

- urinary tract infections;

- septicemia, bacteremia, peritonitis;

- infectious damage to the joints and bones of the body;

- infections of soft tissues, including infection with burns.

As a preventive measure for infections, the use of the drug "Cefotaxime" is also recommended.

The use of the drug after surgery (surgery on the intestine, urological, gynecological) helps prevent the occurrence of complications associated with the accidental entry into the wounds of pathogens.

The drug "Cefotaxime". Description of contraindications for use

A broad-spectrum antibiotic, which is Cefotaxime, may in some cases exert adverse effects on the patient's body. In this case, they talk about contraindications to the use of this drug. To the list of cases when treatment with the drug "Cefotaxime" is not recommended, the instructions for use include:

- the child's age;

- a special sensitivity to the antibiotic "Cefotaxime". It is contraindicated in people who have high sensitivity to penicillins, carbapenems, other cephalosporins.

Caution should be given to Cefotaxime newborns, patients with severe renal failure (chronic forms), with peptic ulcer.

If during the lactation period there was a need for treatment with the drug "Cefotaxime", the instruction for use recommends for this period to stop breastfeeding the baby.

To date, there is no information about medical observations regarding the use of the drug "Cefotaxime" during pregnancy. Treatment can be considered justified if it is vital for a woman and prevails over the potential risk to the health of the fetus.

The drug "Cefotaxime". Side effects

Reception of the antibiotic "Cefotaxime" can cause the patient some negative reactions that occur symptomatically on the part of various body systems.

First of all, the digestive system can negatively react, since Cefotaxime has a strong inhibitory effect on the intestinal microflora. Often in such cases, the patient is disturbed by vomiting, nausea, diarrhea. Negative influence can be manifested even in the form of cholestatic jaundice, hepatitis.

Often there are changes in the hematopoiesis system, manifested in the form of thrombocytopenia, leukopenia, hemolytic anemia.

Negatively reacts to taking this antibiotic and the central nervous system, in a number of cases, dizziness and headache are disturbed. Rash, itching, angioedema (rarely) are allergic reactions arising from the use of the drug in treatment.

In medical practice, there are cases of negative effects of the active substance of the drug on the cardiovascular, urinary systems, as well as the manifestation of local reactions (painful sensations at the site of intravenous administration).

There are no special instructions for the storage of the drug "Cefotaxime", it is enough only to observe the expiration date indicated on its packaging and to find a cool dark place, hard to reach for children.