Anti-TB medicine 'Isoniazid': instructions for use

This publication is devoted to the drug isoniazid. Reviews about the drug are generally good, because it is suitable for the treatment of tuberculosis of any location. The international name of this medication is "Isoniazid". It is included in the group of anti-tuberculosis drugs. It is produced both in solutions and in tablets.

Reporting on the pharmacological properties of the anti-tuberculosis medication "Isoniazid", the instructions for use focuses on its bactericidal action. The drug inhibits the synthesis of mycolic acids and shows a pronounced activity to rapidly multiplying microorganisms.

With respect to the indications, the application instruction specifies that the drug is used for tuberculosis in children and adult patients. It implies a combination therapy in the aforementioned pathology of any etiology.

Are there any contraindications to the treatment with Isoniazid? Instructions for the use of this drug, first of all, draws the attention of consumers to:

• Increased sensitivity to the active substance.

• Medicinal hepatitis and other liver problems (insufficiency). Especially one should be careful in cases of exacerbations. Then the medicine in question is categorically contraindicated!

• With alcoholism, seizures, the drug is prohibited.

• In pregnancy, the dose should not exceed 10 mg / kg.

• Contraindicated in angina pectoris, hypothyroidism, arterial hypertension.

We turn to the side effects of the drug "Izoniazid." Instructions for use indicate the following:

Nervous system: headaches, weakness, fatigue, dizziness. Possible euphoria, insomnia, mood changes, can numb limbs. Epileptic patients showed more frequent seizures.  

CCC: high blood pressure, angina pectoris, palpitation.

Digestive system: hepatitis (toxic), vomiting or nausea, gastralgia.

There were also reactions to the drug, such as arthralgia, hyperthermia, skin rash, itching. After injections, in rare cases, irritation occurs at the point of injection of the needle. Very rarely there were bleeding, hemorrhage (with the propensity of the patient), menorrhagia, gynecomastia.

How to take the described medicine

Use the drug after ingestion inside a dosage of 600 to 900 mg per day. The maximum single dose of the preparation "Isoniazid" instructions for use calls ½ grams per day. Intramuscularly applied 5-12 mg per kilogram of weight during the treatment period from two months to six months. Intravenously injected slowly - up to 15 mg per kilogram of weight once a day. The course of this treatment is from 30 to 150 injections.

Having received the necessary dose of the drug, the patient must comply with bed rest for at least an hour and a half.

For prophylactic purposes, the medicine "Isoniazid" is taken orally. In a day in this case, two doses are necessary for two months. Pregnant women and patients with severe pulmonary heart disease do not receive a dose exceeding 10 mg / kg. The same applies to the appointment of the pharmaceutical agent "Izoniazid" with severe atherosclerosis, pulmonary heart failure. Given the possibility of microbial resistance, the drug is prescribed along with other drugs.

Applying the described means, it is necessary to take into account some of its features. Avoid eating cheese. Refrain from fish in your diet: sardinella, tuna. At the slightest sign of toxic hepatitis, treatment with the drug is canceled.

When using the drug "Isoniazid" overdose is accompanied by disorientation and lethargy, impaired hepatic functions. At the slightest suspicion of poisoning with a medicine, you should perform gastric lavage and seek the help of specialists!