Analogues of "Koraksan": description and instructions for use

What are the analogues of Koraksan? The answer to this question you will find in the materials of this article. In addition, we will provide you with information on what is needed for such a drug, how it should be taken, etc.

General information about the medicinal product

The Koraxan tablets are a preparation that slows down the heart rate. This drug contains in its composition an active substance such as ivabradine hydrochloride, as well as auxiliary components in the form of lactose monohydrate, magnesium stearate, corn starch, maltodextrin and colloidal silicon dioxide.

pharmachologic effect

Coracsan analogs, as well as the preparation itself, regulate the heart rate by selective and specific inhibition of the IF channels of the sinus node, which also controls spontaneous diastolic depolarization. The active active substance of this agent acts on the atrioventricular and intraventricular conduction pathways, as well as on ventricular repolarization and myocardial contractility.

Among other things, ivabradine hydrochloride can interact with the retinal IF-channels, similar to cardiac IF channels, which participate in the onset of temporary changes in visual perception. However, the main pharmacological feature of this substance is the ability to reduce the heart rate.

Indications for use of a pharmacy

What are the analogues of "Koraksan" used for, and also the tool itself? These drugs are prescribed in the following cases:

• Stable angina. Therapy of this disease with the help of this remedy is performed in patients with normal sinus rhythm in the presence of contraindications and intolerance to beta-blockers, as well as in combination with them.
• Heart failure (chronic). With such a deviation, the preparation and analogues of Coraxan are used to reduce the incidence of cardiovascular complications. After all, the large mortality of patients is associated with precisely these diseases.

Contraindications to the use of medicament "Koraksan"

Analogues of the preparation "Koraksan" and the medication itself are not recommended for use in the following cases:

• Hypersensitivity to ivabradine hydrochloride or any of the auxiliary components of the agent;
• Unstable angina ;
• Cardiogenic shock;
• Bradycardia (that is, with a heart rate of at least 60 beats per minute at rest);
• Myocardial infarction (acute);
• Hepatic insufficiency (severe);
• Severe arterial hypotension (at arterial pressure less than 90 mm Hg and diastolic - less than 50 mm Hg);
• Weakness of the sinus node;
• Presence of an electrocardiostimulator;
• Sinoatrial blockade;
• Lactation and pregnancy;
• Atrioventricular blockade of the 3rd degree;
• Simultaneous use of potent inhibitors of cytochrome system isozymes (eg, preparations "Ketoconazole", "Erythromycin", "Itraconazole", "Josamycin", "Clarithromycin", "Ritonavir", "Telithromycin", "Nefazodone" and "Nelfinavir");
• Minority (the safety and effectiveness of the use of this tool to 18 years have not been studied);
• Lactose intolerance.

Take with extreme caution!

Medication "Koraksan" (price, analogues of this remedy will be presented below) should be used only for the doctor's prescription. With extreme caution, these tablets should be taken with:

• Hepatic insufficiency (moderately pronounced);
• Lengthening of the QT interval (congenital);
• Renal failure (severe);
• Simultaneous administration of drugs that extend the QT interval;
• Simultaneous use of grapefruit juice and inhibitors of cytochrome isoenzymes;
• Asymptomatic disruption of the left ventricle;
• Atrioventricular blockade of the 2nd degree;
• Stroke (recently transferred);
• Retinal pigmentation (its degeneration);
• Hypotension;
• Simultaneous administration of calcium channel blockers (for example, Diltiazem or Verapamil).

The preparation "Koraksan": instructions for use

Analogues of this remedy suggest practically the same methods of application and dosage as the named medicine. But before using them, you should always read the attached instructions and consult your doctor.

• With stable angina, this drug in the initial dose is prescribed in an amount of 10 mg per day. If after 3-4 weeks the therapeutic effect has not come, the daily dosage should be increased to 15 mg per day.
• In chronic heart failure, such a drug in the initial dose is prescribed in an amount of 10 mg per day. If after 2 weeks the therapeutic effect has not come, the daily dosage should be increased to 15 mg per day.
• For patients aged 75 years, the recommended initial dose is 2.5 mg twice daily. In the future, you can increase the dose of the drug.
• For violations of kidney function, patients are prescribed a drug "Koraksan" in the amount of 10 mg per day. If after 3-4 weeks the therapeutic effect has not come, the daily dosage should be increased to 15 mg per day.
• When violations of the liver, patients are prescribed a drug "Koraksan" in the amount of 10 mg per day. If after 3-4 weeks the therapeutic effect has not come, the daily dosage should be increased to 15 mg per day.

Possible side effects after taking medication

Despite the effectiveness, not every person with heart problems hastens to take this medication. First of all, this is due to the fact that he has many side effects:

• Blurred vision and frequent changes in light perception (or so-called photopsy).
• Bradycardia, sinus arrhythmia, ventricular extrasystole, angina (unstable), palpitations, myocardial infarction, arterial hypotension, supraventricular extrasystole, atrial fibrillation, ventricular tachycardia and myocardial ischemia.
• Diarrhea, nausea and constipation.
• Headaches (especially in the 1st month of treatment), dizziness, shortness of breath, muscle spasms, vertigo and fainting.
• Hyperuricemia and eosinophilia.
• Skin rash, angioedema, itching, urticaria and erythema.
• Asthenia, malaise and fatigue.

The drug "Koraksan": reviews, analogues of the drug

Those who have repeatedly used this tool, speak about it only positively. However, such a drug is very expensive. So, for 56 tablets of medicament "Coraxan" you will have to pay about 1200 Russian rubles. In this regard, most patients with heart disease more often began to buy cheaper analogs of the drug.

The following medicines can be classified as structural analogues of this agent for the active substance:

• Ivabradine hydrochloride;
• Iwabradine.

According to the curative effect (preparations intended for the therapy of angina pectoris):

• Amlodipine;
• Asparks;
• Atenolol;
• "Aspirin Cardio";
• Betalok;
• "Validol";
• Hypoxen;
• "Isoket";
• Diltiazem;
• "Isolong";
• Carvedilol;
• Concor;
• "Corvitol";
• Lokren;
• "Cordipin";
• Corinthard retard;
• Metoprolol;
• Mildronate;
• "Monosan";
• "Nitroglycerine";
• "Papaverine";
• "Nitrogen";
• "Nifedipine";
• "Normodipin";
• "Plavix";
• "Prestans";
• Stamlo;
• "Sustonite";
• "Trimetazidine";
• "Tenox";
• "Egilok";
• "Efoks Long" and others.