Analogues, instructions for the use of "Naropina." Customer Reviews

Anesthetics are drugs that have the ability to cause anesthesia.

Anesthesia is a decrease in the sensitivity of the body or parts of it. Also for such a state, a complete cessation of the perception of information about the state of one's body and the environment is characteristic.

In medical practice, the drug "Naropin" is often used as an anesthetic. Instructions for use, feedback from specialists will be described below.

Composition, form of production and packaging

The drug "Naropin", the instruction to which is contained in a cardboard pack, is available in the form of an injection solution. It can include 2, 5, 7.5 or 10 mg of an active ingredient, such as ropivacaine hydrochloride.

As for additional components, they use acid hydrochloride or sodium hydroxide, as well as water for injection and sodium chloride.

In the sale of this product comes in ampoules.

Pharmacological features of the drug

What is a medicine like Naropin? Instructions for use asserts that this is an anesthetic of the amide series, which is designed for anesthesia and local anesthesia.

The use of small dosages of ropivacaine promotes blockade of the sensitivity of a certain part of the body with limited non-progressive motor activity.

In high doses, this medicine leads to surgical anesthesia.

Properties of the preparation

What is remarkable about the drug "Naropin"? Instructions for use indicate that the effectiveness of this tool is due to its ability to reversibly reduce the permeability of nerve fiber membranes. Due to this effect, the threshold of excitability increases and the rate of depolarization decreases, which, in turn, leads to local blocking of nerve impulses.

When using increased doses of the drug, its suppressing effect on the cardiac muscle and CNS is noted (conduction worsens, automatism and excitability decrease).

For ropivacaine is characterized by a prolonged effect. The duration of the therapeutic effect of this drug can be controlled by dosage.

With epidural administration of the drug, it takes two-phase and complete absorption from the epidural space. The concentration of ropivacaine in the blood depends on the way it is used.

Kinetics of the drug

Instructions for use ("Naropin" should be administered only by an experienced anesthesiologist) reports that this drug has a linear pharmacokinetics. Due to this, its maximum concentration in the blood is proportional to the administered dosage.

The connection with plasma proteins is 94%.

Epidural administration of the drug for a long time increases the total plasma concentration of ropivacaine.

The active substance of the agent in question undergoes a rapid metabolic transformation. In the initial phase, the half-life period is ¼ hour, and in the terminal phase - 240 minutes.

With intravenous administration of the drug, 86% of its dose is excreted by the kidneys.

Indications

What is the purpose of using such a drug as Naropin? Instructions for use (in the dentistry this drug is administered very often) states that this medication is intended for anesthesia during surgical interventions:

• For blockade of large nerves and nerve plexuses.
• For the purpose of infiltration anesthesia and blockade of individual nerve fibers.
• For epidural blockade for the purpose of conducting operations, including cesarean section.

It should also be noted that the drug "Naropin" is often used for relief of symptoms in acute pain syndromes:

• For prolonged blockade of peripheral nerves.
• For intraarticular injections.
• For the purpose of infiltration anesthesia and blockade of individual nerve fibers.
• With epidural prolonged infusion, periodic bolus injection or to prevent pain in postoperative time, and also for the purpose of anesthesia during labor.

It should also be noted that the drug "Naropin", the instruction for use of which is presented below, is actively used for relief of symptoms in acute pain in pediatric practice:

• For caudal epidural blockade in children under 12 years of age, including newborn babies;
• For prolonged epidural infusion in children under 12 years, including newborn babies.

Contraindications

What contraindications does the anesthetic "Naropin" have? Instructions for use (for spinal anesthesia this remedy should only be prescribed by an experienced anesthetist) indicates the following prohibitions:

• Hypersensitivity, manifested to anesthetics of the amide series (including in the anamnesis).
• Hypersensitivity to ropivacaine and other components of the drug.

It should also be noted that the drug "Naropin", the dosage of which should be selected only by a narrow specialist, is cautiously prescribed to elderly and weakened patients, as well as patients with severe diseases, including blockade of intracardiac conduction, liver and kidney pathologies.

Extremely cautious local anesthetic must be injected into the head and neck because of the increased risk of developing serious adverse reactions.

Special care is required when administering the medication intraarticularly, especially with extensive injuries and surgical intervention. Otherwise, this can lead to increased absorption of the drug and an increase in its plasma concentration.

Due to the underdevelopment of functions and organs in children up to six months, anesthesia in this age group should be carried out with extreme caution.

Drug "Naropin": instructions for use for children

Reviews about this medicine will be presented further.

When epidural caudal introduction to stop pain syndromes with children weighing up to 25 kg, blockade with injection solution at a dose of 2 mg / kg.

Epidural or bolus infusion introduction of the drug is carried out in accordance with the age of the child:

• 6-12 months: infusion - 0.4 mg / kg / h, bolus - 1 mg / kg;
• Up to six months: infuzionno - 0.2 mg / kg / h, bolus - 1 mg / kg.
• 1-12 years: infusion - 0.4 mg / kg / h, bolus - 2 mg / kg.

"Naropin" solution: instructions for use

In ampoules, this anesthetic is sold in all pharmacies.

For adults, the dosage of the drug is selected by a specialist. An anesthesiologist should be guided by his clinical experience, as well as take into account the individual state of the patient's body.

For epidural administration, 15-25 ml of solution is used in surgical procedures. In this case, the onset of action of the drug is observed after 20 minutes and lasts for 5 hours.

A similar amount of the drug is also used in cesarean section.

Blockade of large plexus plexuses is carried out by epidural medication on the thoracic level in an amount of 5-15 ml.

Conducting and infiltration anesthesia with application of 1-30 ml of solution leads to the onset of the effect after 5-15 minutes with a duration of 2-6 hours.

Special Recommendations

The dosage of the drug "Naropin" for spinal anesthesia is selected depending on the general condition of the patient. The same goes for the blockade of nerve fibers.

Anesthesia of the brachial plexus can be accompanied by serious side effects.

With simultaneous use of other types of anesthetics, the maximum dosage of "Naropina" should not be above 225 mg.

In order to prevent accidental introduction of the drug into the vessel, the aspiration test must be performed without fail before the procedure begins and during the procedure.

The introduction of a medication is intravascularly recognized by a temporary increase in heart rate. When observing the toxic effect, the solution must be discontinued immediately.

During anesthesia, it is necessary to monitor the normal operation of vital organs and patient systems. It is also necessary to maintain regular verbal contact with him.

Adverse events

Negative reactions that are noted in the application of the agent in question are similar to those used with other anesthetics of the amide series. It is necessary to distinguish between side effects from the physiological symptoms that arise from the blocking of sympathetic nerves.

The drug "Naropin" for spinal anesthesia can cause the development of bradycardia and hypotension. Also during anesthesia, the following undesirable reactions are observed in patients:

• Nausea, tachycardia, headaches, hypothermia;
• Lowering blood pressure, cramps, back pain, dyspnea;
• Vomiting, fainting, hypertension, fever;
• Paresthesia, dysarthria, chills, anxiety;
• Dizziness, tremor, urinary retention.
• Hypoesthesia, shortness of breath, numbness of the tongue;
• Convulsive attacks, ringing in the ears, urticaria;
• Paresthesia in the perioral zone, arrhythmia, visual impairment;
• Quincke's edema, cardiac arrest, muscle cramps;
• Anaphylactic phenomena.

Analogues

How can you replace an anesthetic like Naropin? Instructions for use will not give an answer to this question. Behind it you will have to turn to an experienced anesthesiologist.

As a rule, instead of Naropin, specialists very often use such drugs as Articaine, Bupivacaine, BlockcoS, Alfacaine SP, Lidocaine, Brilocaine-adrenaline, Mepivacaine, Pyromecaine, Marcain, Scandonest, Ultrakain, Cytokartin, Trimekain, Hirokain, and others.

It should be noted immediately that the methods of administration and dosage of these agents may differ significantly from those of the drug "Naropin."

Reviews

Now you know how and for what purpose use such an antibiotic as "Naropin." Instructions for use, analogues of this medication were presented above.

Most often, the anesthetists leave their comments about the drug under consideration. And this is not surprising, because this drug is designed for small and large operations.

In the overwhelming majority of the responses of experts are positive. Summarizing the opinions of doctors, this anesthetic can be characterized as a time-tested, reliable and affordable medicine.

As for patients, their feedback about this drug is almost not found.