The medicine Perindopril. Instructions for use

The drug "Perindopril" lowers blood pressure, normalizes heart activity. The use of the drug can reduce the burden on the heart. With prolonged use of the drug, the elasticity of large arteries is restored, the degree of hypertrophy of the left ventricle decreases. Its active ingredient is perindopril, it is a part of many drugs. For example, such a drug is Perindopril + Indapamide. This combined medicine has vasodilating (vasodilating), diuretic and hypotensive action.

After taking medication "Perindopril", the maximum hypotensive effect is noted within four to six hours. The effect of the drug, as practice shows, persists for 24 hours. In more susceptible patients, there is a very rapid decrease in pressure. A stable hypotensive effect is observed a month after the start of treatment.

With the termination of the use of the drug, the so-called "withdrawal syndrome" usually does not arise. In chronic heart failure , Perindopril (an instruction for use contains such information) helps to reduce myocardial hypertrophy of the left ventricle, normalize the isoenzymatic profile of myosin, normalize the formation of subendothelial collagen.

Against the background of taking the remedy there is a decrease in the filling pressure of the right and left ventricles and the overall peripheral resistance in the vessels. The heart rate decreases moderately. The use of Perindopril in recommended dosages for the treatment of heart failure contributes to the reduction of its manifestations.

Prolonged use of the drug does not provoke disturbances in the activity of the kidneys and does not affect the level of potassium in the blood. The drug is well absorbed from the digestive tract. Eating does not affect the degree of absorption.

With hypertension, Perindopril recommends that the dosage be taken at a dosage of four milligrams per day. A month after the start of therapy, if necessary, the daily dose may be doubled (up to eight milligrams, once a day). The drug "Perindopril" instruction for use recommends taking in the morning.

For patients older than seventy years, previously taking diuretics, the initial dosage is two milligrams, once a day. A month after the start of therapy, if necessary, the dose is increased to four milligrams per day.

With renal failure, the amount of Perindopril should be set individually. In chronic heart failure, the initial dosage is two milligrams a day. The maintenance dosage is 2-4 milligrams per day.

With caution, the drug is prescribed for liver failure, arterial hypotension. If an operative intervention is necessary, the anesthetist should be warned that the patient is taking Perindopril medication. Contraindicated drug in lactation, hypersensitivity, as well as in childhood and during pregnancy.

To adverse reactions with the medication "Perindopril" instructions for use include dyspepsia, alopecia, fever, angioedema, stomatitis, headache. The drug can cause hives, cramps, dry mouth, weakness. In some cases, sleep disorder, thrombocytopenia, chest pain, arterial hypotension, anemia are observed. Taking Perindopril can cause kidney impairment, impotence, increased serum creatinine and urea levels (especially with the simultaneous use of diuretic drugs).

When an overdose often occurs angioedema, arterial hypotension (acute). The patient is prescribed symptomatic therapy, the usual detoxification measures (gastric lavage). The appointment of antihistamines.

Before taking the medicine "Perindopril" it is necessary to consult a doctor.