The drug "Divigel" for the growth of the endometrium: reviews of doctors and patients, dosage

The problem of female infertility in our time is quite acute. The causes can be different - from various inflammatory diseases of the genital area and to problems in the endocrine system. One of the most common causes is the insufficient number of female estrogens. Their main task is to prepare the inner layer of the uterus for the adoption of the egg.

To eliminate this deficiency, doctors prescribe to women drugs containing this hormone. One such drug is the "Divigel" for the growth of the endometrium, the responses of the patients about it are positive, and many women manage to get pregnant safely.

Structure of the preparation

"Divigel" is manufactured by manufacturers in the form of a transdermal gel, serving to eliminate signs of a lack of estrogens. It is a uniform composition and packed in aluminum bags.

In its composition, the gel has:

• Estradiol in the amount of 500 mg or 1 g.
• Carbomer 974R.
• Triethanolamine.
• Propylene glycol.
• 96% ethyl alcohol.
• Purified water.

Pharmacological action of the drug

"Divigel" refers to a group of medicines that are used to correct violations caused by menopause in a woman's life. It has an estrogenic effect.

The therapeutic effect after application is achieved as a result of the activity of estradiol. This estrogenic remedy, which contains the "Divigel" for the growth of the endometrium, is identical in its biological, chemical and pharmacological properties to the endogenous estradiol synthesized by the ovaries in the female body.

If you look at the classification of medicines, then estradiol is referred to several pharmacological groups:

1. Estrogens, gestagens, their antagonists and homologues.
2. Antineoplastic hormones and hormone antagonists.

The active substance of the drug replenishes the lack of female hormones and stimulates the activity of estrogen receptors located in the target cells.

Pharmacokinetics

Estradiol contained in the gel diffusion freely penetrates into target cells, where it is transported to the nucleus and forms a bond with estrogen receptors. Such receptors are found in different tissues. But most of them are contained in the uterus, liver, ovaries, bones and mammary glands.

The active component of the gel - 17-beta-estradiol - has the following effects:

• Stimulates the development of the female reproductive system.
• Causes pigmentation in the nipple area.
• Provides rejection of the endometrium, which lining the uterus.

• Provides a regular menstrual cycle.
• It stops the production of breast milk.
• Has a procoagulant effect.
• Influences positively on the restoration of the number of leukocytes after radiation damage.

Estradiol still has many important qualities, which include:

• Prevention of atherosclerosis.
• Increase in blood levels of HDL.
• Decreased LDL cholesterol.
• Decreased cholesterol.

After the onset of menopause in the body, ovaries stop producing estradiol, this function remains in the liver and adipose tissue. Decrease in the level of estrogen leads to the fact that there is vasomotor instability, expressed in the tides of blood to the face, problems with sleep.

Another negative consequence of the lack of estrogen is the development of osteoporosis. This metabolic disease is captured primarily by the spine.

When taking estradiol inward in the form of tablets, injections, a gradual accumulation in the body of this substance takes place, which leads to a significant jump in blood pressure. "Divigel" for the growth of the endometrium reviews in this regard is positive, the patient during admission does not mark hypertension.

The gel is made on an alcohol basis, but after getting on the skin, ethanol quickly evaporates, and the active substance penetrates through the integument and is absorbed into the blood. A small amount of estradiol is retained in the skin, and then gradually released into the bloodstream.

During the course of treatment "Divigel" the ratio between estradiol and estrone is from 0.4 to 0.7. Biological availability of the drug is 82%. The effectiveness of therapy will directly depend on how to apply the "Divigel" for the growth of the endometrium.

Indications

This gel is recommended for doctors to take hormonal replacement therapy for women who have a shortage of estrogen for various reasons. The drug is often prescribed to eliminate menopausal syndrome.

Gel has proven itself as a preventive agent, which prevents the development of osteoporosis. Positive feedback has the "Divigel" for the growth of the endometrium with IVF as a drug that supports the normal course of pregnancy.

The drug is administered in an individual dosage, which is selected by the attending physician in the clinic where the fertilization procedure was carried out. Start using it better for a couple of weeks before fertilization and continue after it for about a month.

After the onset of pregnancy, discontinuation of use can not be made abruptly, since in this case there is a risk of spontaneous miscarriage.

If a "Divigel" is assigned for endometrial growth, the dosage is selected in each case separately. During the pregnancy planning period, the doctor must be sure of the presence of endometrial hypoplasia, to stimulate ovulation, it is advisable to combine the gel with other hormonal preparations. In each of these cases, the treatment regimen will be different.

Contraindications for use

Before you figure out how to take the "Divigel" for the growth of the endometrium, you need to make sure that there are no contraindications to this, and there are enough of them for the drug. Among them, the most common are the following:

1. Hypersensitivity to components.
2. The presence of breast cancer or if it was in history.
3. Malignant formation in the ovaries, uterus.
4. The presence of benign tumors in the genitals, in the chest.
5. Predisposition to uterine bleeding.
6. Hyperplastic processes of the endometrium.
7. Pituitary tumors.
8. Inflammatory diseases of the genital organs.
9. Increased estrogen content.
10. Thrombophlebitis.
11. Presence of tumors in the liver.
12. Signs of impaired cerebral circulation.
13. Sickle-cell anemia.
14. Disturbance of fat metabolism.
15. Diabetes.
16. Diseases of the middle ear.

Particular care during the use of the gel must be observed for women who are observed:

• Bronchial asthma.
• Attacks of a migraine.
• High blood pressure.
• Heart, kidney or liver failure.
• Diseases of the heart.
• Propensity to edema.
• Fibrous-cystic mastopathy.

Presence of all these contra-indications and warnings testifies that before finding out the question of how to smear "Divigel" for the growth of the endometrium, it is necessary to visit a specialist without fail and discuss this issue with him.

Unwanted consequences

Each organism is individual, in its own way perceives the effects of drugs, so even the absence of contraindications to use does not mean that there will be no side effects. In the course of treatment with gel, they can be as follows:

1. From the nervous system: headache, dizziness, migraine attacks, depression.
2. On the part of the heart and blood vessels: thrombophlebitis and persistent increase in blood pressure.
3. The digestive system can respond with nausea, vomiting, pain in the stomach, flatulence.
4. On the part of the reproductive system can be observed: vaginal bleeding, persistent discharge, enlargement of the endometrium, changes in libido, cancer of the uterus.
5. The endocrine system can exhibit the following symptoms: the appearance of excess weight, engorgement of the mammary glands.

With prolonged use of the gel, fluid can accumulate in the body, leading to swelling. Given that the drug is used externally, the skin can develop allergic rashes, itching.

Some patients who use the "Divigel" for the growth of the endometrium, the reviews leave negative because of frequent manifestations of such side effects as visual impairment and severe vaginal candidiasis.

To avoid all undesirable consequences, use the drug strictly according to the doctor's prescription.

How to take the "Divigel" for the growth of the endometrium

The drug with good tolerability and the absence of contraindications can be used for long-term therapy. At the initial stage of treatment, the dosage is 1 g of gel. After several courses, taking into account the change in the picture in the patient, the dosage can be increased or decreased.

It is very important to find out from the doctor not only where to spread "Divigel" for the growth of the endometrium, but also on what day of the monthly cycle it should be started.

According to the instructions, the gel should be applied to clean skin in the area of the lower abdomen, waist, shoulders, forearms or buttocks. It is desirable to do this at the same time every day, the area of application must be alternated.

The most optimal area for application is the size of 1-2 palms. The treatment site can not be washed for an hour after using the gel.

If a woman forgets to apply the gel, then it should be done no later than 12 hours from the time of application of the drug on a schedule. If more time has passed, then it is worthwhile to postpone it until the next time.

If the dose is exceeded

Many believe that if you take the drug in a larger dosage, then the onset of a positive effect will occur faster, but this is not at all the case. If the doctor's recommendations for using the "Divigel" and exceeding the dosage are exceeded, the following symptoms may be observed:

• Soreness in the chest.
• Bloating.
• Appearance of a sense of anxiety.
• Irritability.
• Attacks of nausea.
• Vomiting.

When these symptoms appear, you should discuss with your doctor and change the dosage or cancel the drug.

"Divigel" in combination with other means

If the doctor prescribes a "Divigel", it is necessary to first ascertain which medications the patient takes. Estradiol can have the following effects:

• To increase the effectiveness of lipid-lowering drugs.
• Weaken the effect of drugs that include male sex hormones.
• Weaken the effect of drugs used in diabetes mellitus.
• Reduce the effectiveness of drugs against hypertension.
• Weaken the therapeutic effect of anticoagulants.

Accelerates the metabolism of estradiol co-administration:

• Barbiturates.
• Narcotic analgesics.
• Means used for anesthesia.
• Some antiepileptic drugs.

The effectiveness of the "Divigel" will significantly decrease if it is used together with some antibiotics, as well as with "Phenylbutazone". To enhance the effect, you can take with him folic acid preparations and for the thyroid gland.

Special Recommendations

"Divigel" for the growth of the endometrium reviews of doctors receives more positive, only specialists recommend appointing it after a thorough examination of the patient and detailed conversation with her.

To avoid undesirable consequences, a woman should undergo a complete examination of the pelvic organs and mammary glands. It must be regularly passed and throughout the treatment.

We examined, "Divigel" for the growth of the endometrium where to smear, in which area. It is important then to wash your hands with soap and do not touch your eyes.

Do not apply gel to the area of the pectoral and sexual glands, as well as to places where there is irritation. The use of "Divigel" can disrupt the process of ovulation. The synthesis of hormones directly depends on the concentration of estrogens in the blood, and when they enter from the outside, it can be disturbed, so taking the drug when planning conception is very careful.

Application of the drug during pregnancy and lactation

Despite the fact that the "Divigel" for the growth of the endometrium reviews with IVF gets good, when the onset of pregnancy is worth discussing the tactics of its further application with the doctor. If the diagnosis of an interesting situation in a woman is not in doubt, then most likely, the doctor will decide to stop using the drug.

Various studies show that one-time and occasional use of the gel during pregnancy does not cause a teratogenic effect, but it is not worthwhile to risk the health of the baby's future.

During the period of breastfeeding, it is prohibited to apply the gel.

Women's health is a fragile thing, it can malfunction at the most inopportune moments of life. Nobody wants to stuff your body with chemical preparations, but there are situations when the "Divigel" is simply necessary for the growth of the endometrium, reviews, especially, it gets excellent. Positively, this drug is characterized not only by doctors, but also by patients, especially in the climacteric period.

It is not superfluous again to remind that any treatment should be prescribed only by a competent specialist, you should not take such serious medications on the advice of a friend or when you see an advertisement on television. Take care of your health!