HealthPreparations

Drug "Jardines": user manual, reviews, analogs, photo, manufacturer

Diabetes mellitus is a serious disease that can not be ignored in any case. Despite the fact that there are no drugs that can cure for a long time from the disease, with the help of the correct administration of certain drugs, it is possible to reduce the manifestations of the ailment to a minimum and provide the patient with a relatively high standard of living.

One of the drugs prescribed for type 2 diabetes is a remedy called Jardins. The instructions for using the drug are quite simple, and the effect of therapy is noticeable. That is why in modern medicine this medicine is used quite often. And information about the preparation becomes more and more popular. For example, in what form is it produced and how does it affect the body? Is it possible to have severe adverse reactions? Are there any contraindications to admission? How much is the medicine and can I replace it with something? Many patients are looking for answers to these questions.

Description of the form of release and composition

The drug "Jardins" (photo of the package see above) is available in the form of round biconvex tablets, coated with a film sheath. They are painted in a pale yellow color. The main active component of the drug is empaglyflosin. On the modern pharmacological market, a drug with a different dosage is produced - one tablet can contain 10 or 30 mg of the active substance.

Naturally, the drug contains other, auxiliary components. In particular, lactose, magnesium stearate, croscarmellose sodium, microcrystalline cellulose, anhydrous colloidal silicon dioxide, hydroxypropylcellulose. The film shell contains macrogol 400, hypromellose, yellow iron oxide, titanium dioxide and talc.

Main pharmacological properties of the drug

Quite often in modern medicine the drug "Jardins" is used. Experts say that the drug allows you to achieve really good results. But how does this medicine work on the human body?

Empagliflozin is a selective, reversible, highly active competitive inhibitor of the sodium-dependent glucose transporter of the second type. As studies have shown, this substance improves glycemic control in patients suffering from type 2 diabetes. Empagliflozin reduces the level of glucose reabsorption by the kidneys. As you know, the amount of glucose that is excreted by the kidneys depends on its concentration in the blood, as well as the glomerular filtration rate. In patients taking these tablets, the amount of glucose released with urine increased. Thus, the drug provides an immediate reduction in blood sugar in patients with type 1 diabetes.

The mechanism of action of the drug in no way depends on the effect of insulin or on the function of beta cells of the pancreas, and therefore the risk of developing hypoglycemia is small. It has also been observed that the drug improves the work of beta cells, but also contributes to the fat burning process, leads to a decrease in body weight, which is considered useful if the patient suffers from excess weight.

Pharmacokinetics and additional information

There is a large amount of data on the pharmacokinetics of this drug, obtained through laboratory tests (patients with a second type of diabetes mellitus took part in them).

After taking the main active substance of the drug is quickly absorbed, penetrating through the walls of the digestive tract. The maximum concentration in the blood of the patient is observed after 1-1,5 hours after administration. After that, the amount of empagliflozin in the plasma decreases - first there is a rapid phase of drug distribution, and then a relatively slow final period of metabolism of the active substance.

During the studies, it was noted that the intensity of the systemic effect of empaglyflosin increased with increasing dose of the drug. Also, tests have shown that if you take the medicine with a high-calorie, fat-rich food, its effectiveness decreases slightly. Nevertheless, this change is not clinically significant, and therefore the tablets can be consumed regardless of food intake.

The active substance of the drug binds to 86% of the blood plasma proteins. During studies in the human blood, three glucuronide metabolites were detected, but their systemic amount was no more than 10% of the total level of empaglyflosin.

The terminal elimination half-life of this drug is about 12-12.5 hours. If patients took tablets once a day, a stable level of active substance in the blood was observed after the fifth dose. As already mentioned, the drug practically does not form metabolites. Most of it is excreted from the body together with feces, the rest - kidneys along with urine, and in an unchanged form.

Also during the research it was determined that neither the weight nor the sex of the patient affected the effect of the drug. Testing on a group of patients older than 85 years, as well as among children and adolescents was not conducted, and therefore there is no data on the safety of this medication for these categories of patients.

Despite the mechanism of drug exposure, the success of therapy largely depends on the functioning of the kidneys. That is why before starting taking tablets, it is worthwhile to conduct a complete examination of the excretory system, as well as to pass urine tests. Such checks should be repeated periodically during treatment (at least once a year). In addition, the tests should be taken and in those cases if new drugs have been introduced into the therapy regimen. It should be said that in patients who take this medicine, the glucose test will be positive in laboratory urinalysis - this is perfectly normal, since it is related to the peculiarities of the effect of empaglyflosin on the body.

To date, there is no information about how the drug affects the body of the pregnant mother and fetus, and whether the active substances penetrate into breast milk.

The main indications for taking the medicine

When is the drug Jardins appropriate? Instructions for use indicate that in modern medicine the medicine is used in the following cases:

  • Diabetes mellitus type 2;
  • Improvement and control of glycemia in adult patients.

Monotherapy is carried out in the event that it is not possible to control glycemia in patients even with the right diet and the corresponding pattern of physical exertion, and for one reason or another the use of metformin is impossible (for example, due to individual intolerance).

As part of the complex therapy, this drug is used along with insulin and other hypoglycemic drugs, if the basic treatment regimen, proper diet and physical activity can not normalize the patient's condition.

In any case, it is worth remembering that only a doctor can enter these pills into a course of therapy. Incorrect drug intake can only aggravate the situation, and with such a disease as diabetes, this can lead to serious consequences.

Drug "Jardins": instructions for use

Naturally, an important issue is the scheme for taking these tablets. Only the doctor can choose the right dosage of the medicine "Jardins". The instructions for use contain only general recommendations.

As a rule, patients are recommended to take 10 mg of empaglyflosin once a day - this applies to both combined and monotherapy. In those cases where the patient's body tolerates the drug well, but the usual dose does not give the desired results, the daily dose can be increased to 25 mg. A day is allowed to take no more than one tablet.

Naturally, the dosage is adjusted by the doctor depending on the condition of the patient, his age and, of course, the effect of therapy. Also take into account a set of other medicines that a person takes.

You can drink tablets in the morning on an empty stomach, and later, during or after a meal, since the digestive processes do not significantly affect the absorption and distribution of the active components of the drug.

The duration of the drug depends on the condition of the patient, the level of glucose in the blood. Sometimes a doctor can cancel a medication after hyperglycemia has been taken under control. In some cases, pills are taken for a long time, and sometimes the reception is conducted by courses. This can also be determined only by the attending physician based on the effect of therapy, as well as the results of routine examinations.

Are there any restrictions on admission? Basic Contraindications

Not all patients are allowed treatment with the help of "Jardins" tablets. The instruction testifies that the given medicine has a number of contraindications. With their list it is necessary to read before the beginning of therapy, as otherwise a number of complications may develop. So, the drug can not be used in the following cases:

  • Diabetes mellitus type 1;
  • Presence of diabetic ketoacidosis;
  • The drug "Jardins" is not prescribed in the presence of hypersensitivity to any of the constituent components (be sure to read the composition before taking the medication);
  • Some relatively rare hereditary diseases, for example, lactose intolerance, glucose-galactose malabsorption, a deficiency of lactase (an enzyme that breaks down lactose molecules), etc., are also contraindications;
  • In some forms of renal failure, these pills are also not used, because they simply do not have an effect;
  • The drug has some age limitations, in particular, it is not prescribed for patients under the age of 18, since studies with this group have not been conducted; Also the medicine is contraindicated for the elderly (over 85 years);
  • The drug can lead to a moderate decrease in blood pressure, and therefore to contraindications include some cardiovascular diseases;
  • During pregnancy and breastfeeding the drug is prohibited, since the safety of tablets during these periods of a woman's life is not determined.

The medicine "Jardins" has so-called relative contraindications. This means that taking the drug is possible, but only under the careful supervision of the doctor, since there is a risk of complications. At risk, patients at risk of developing hypovolemia. Also, the tablets are gently used together with synthetic insulin.

Relative contraindications include diseases of the digestive tract, which are accompanied by loss of fluid (diarrhea, vomiting). Tablets with caution are prescribed in the presence of infectious lesions of the genitourinary system. Treatment of patients older than 75 years should also be monitored. In any case, you should definitely tell the doctor about the presence of certain diseases - only so the specialist will be able to prescribe the safest course of treatment.

Possible adverse reactions

It's not a secret to anyone that many medications can cause various side reactions in certain cases. So is there a danger of complications when taking Jardins? The instruction indicates that some complications are possible. Here is a list of the most common side effects:

  • The most frequent reaction is hypoglycemia, although it appears, as a rule, against simultaneous reception of empaglyflosin with synthetic insulin or derivatives of sulfonylurea.
  • Sometimes on the background of therapy, patients developed infectious and parasitic diseases, in particular vulvovaginitis, balanitis, vaginal candidiasis, and also some urinary tract infections.
  • From the side of metabolism can develop not only hypoglycemia, but also hypovolemia.
  • Some patients also complained of frequent urination.
  • Among the elderly patients, dehydration was more common on the background of therapy.

This is the main possible complications, to which the tablets "Jardins" can lead. The reviews, however, suggest that serious side effects are extremely rare. However, if you notice any worsening in the background of therapy, you should immediately consult a doctor. Perhaps a simple change in dosage will be enough to get rid of adverse reactions. On the other hand, in some cases it is advisable to completely cancel the medication, replacing it with another drug.

Information on interaction with other medicinal products

How does the drug Jardins interact with other drugs? The doctors' testimonies show that with a correctly formulated therapy scheme, the patient's health risk is minimal. Nevertheless, the active components of the drug in combination with other substances can affect the human body in different ways:

  • This drug sometimes enhances the diuretic effect of the so-called "loop" and thiazide diuretics. Thus, there is a risk of dehydration and, as a consequence, the development of arterial hypotension.
  • Due to the fact that patients can reduce blood pressure, it is undesirable to combine drugs to increase blood pressure and tablets "Jardins". The doctors' comments, however, indicate that the correct dosage of both drugs reduces the risk to a minimum.
  • As already mentioned, the simultaneous administration of this drug with synthetic insulin and drugs that activate the secretion of the natural hormone in the human body, can lead to the development of hypoglycemia. In such cases, careful monitoring and dosage adjustment are also required.

Drug "Jardins": analogues and substitutes

Not all patients are suitable for this drug. For one reason or another, people can refuse to use the drug Jardins. Synonyms for this drug, of course, exist. Moreover, the modern pharmacological market offers a wide range of drugs that affect the body in this way.

For example, quite often patients are prescribed infusions with solutions of such drugs as "Baeta" and "Victoria". By the way, these are qualitative substitutes from a well-known German firm. Sometimes patients are prescribed a drug "Guarem" in granules. There are other drugs that can replace "Jardines". His analogues are tablets of Invocana, Novonorm and Repodiab.

Despite such a large number of substitutes, in no case can self-medication. Only a doctor who is familiar with your medical history can choose a really good, effective and safe analog. Once again it is worth repeating that diabetes mellitus is a serious disease, and inept use of medications in this case can lead to a mass of complications, up to a lethal outcome.

How much does the drug cost?

It's not a secret for anyone that for many patients the cost of a medicine is very important. It is worthwhile to understand that the figures in this case will depend on many factors. For example, in consideration it is necessary to take the dosage and the number of tablets in the package, the patient's city of residence, the financial policy of the pharmacy and the supplier, and so on.

Drug "Jardins" (the manufacturer - "Boehringer Ingelheim Pharma") with a dosage of 10 mg of the active ingredient will cost 2000-2200 rubles for 30 tablets. If we are talking about a drug with a dosage of 25 mg, the cost will be slightly higher, namely from 2,100 to 2,600 rubles. Cheaper will cost a package with 10 tablets, the cost of which ranges from 800 to 1000 rubles. Now you have the opportunity to draw up an approximate budget for treatment with "Jardins" drugs. Substitute medicine, by the way, can cost more. On the other hand, the price of some other similar drugs is slightly lower. In any case, it is worthwhile to focus not only on the cost, but also on the potential outcome of the treatment, because health costs any money.

Reviews of doctors and patients about the medicine

Surely many people know that, after inquiring about the opinion of patients who have already completed treatment, one can get a lot of useful information. So what do they say about the Jardins drug? The responses of doctors are mostly positive. Indeed, the pills help to normalize the metabolism, improve the condition of patients. According to statistical surveys, side effects on the background of therapy do not occur very often, and they can be avoided by simple dosage adjustment.

The patients themselves also like the medicine "Jardins". Feedback is positive, as the admission scheme is fairly simple, and the positive results appear quite quickly. Tablets do meet high standards of German quality. The shortcomings of the drug can be attributed unless the relatively high cost, as some analogs are much cheaper. On the other hand, similar drugs from European manufacturers sometimes cost two or even three times cheaper.

In any case, it is worthwhile to understand that "Jardins" are tablets that help normalize the body's work in diabetes mellitus type II, but they are not able to get rid of this dangerous disease. Self-medication in this case is inappropriate, but do not forget that it is important to follow all the recommendations and prescriptions of the treating doctor. Proper use of drugs helps to control blood glucose levels and, accordingly, improve the quality of life of a patient with diabetes.

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