Description of the drug thiamine. Instructions for use

Thiamine is available in the form of capsules or intramuscular solution. The second name for the drug is aneurine (obsolete). It is a vitamin that dissolves in water. The substance has no color. When heat treatment - is destroyed. Thiamine does not dissolve in alcohol. What are the functional features of thiamine? Instructions for use describe in detail the purpose of the drug.

Functions of thiamine

Vitamin Thiamine is still known as B1 vitamin. It regulates the metabolism of fats and carbohydrates in the body, stabilizes growth and development, improves the working capacity of the heart, digestive and nervous systems. Since one of its properties - to dissolve in water, the vitamin does not stay in the body and does not decompose into toxins.

The Appearance of Thiamine

History begins when the scientist Christian Aikman first discovered substances such as vitamins. As a result of his discovery in medicine, he became a Nobel laureate. Another scientist, Kazimir Funk, isolated the vitamin as a compound with nitrogen from rice bran. Vitamin as a separate substance was finally obtained in 1926.

Physical and chemical characteristics

Almost complete solubility in water. In acid-aqueous solutions, the high temperature does not affect the substance. In alkalis, when heated, the substance is deformed. The molecule consists of rings of pyrimidine and thiazole formed by a methylene bond.

Distribution in the body

Consider how thiamine is distributed in the body. The instruction describes the pharmacokinetics of the drug. After passing through the GIT, the drug is absorbed and digested by digestive enzymes. Then, within 15 minutes, it enters the bloodstream in an unrelated form. Half an hour later, it spreads in various tissues. In its pure form, thiamine is present in the plasma, and in the form of phosphoric esters - in leukocytes and erythrocytes.

As a percentage of 50% of thiamine is contained in striated muscles, internal organs account for about 40% of the total amount of vitamin. Nerve tissue and liver tissue also contain enough thiamine.

Thiamin diphosphate is the active phosphoric ester that thiamine possesses. The instructions for use indicate that this ether is directly involved in the metabolic processes of fats and carbohydrates. The withdrawal from the body occurs through the kidneys and intestines.

Use

The medication is administered intramuscularly or slowly intravenously once a day. The standard serving for adults is 25 to 50 mg. Treatment time can be from 10 days to one month.

Also, with chronic hypovitaminosis, the medication is taken orally 10-25 mg. The daily dose is single or divided.

In what cases is the dose of thiamine increased? Instructions for use in severe hypovitaminosis vary daily dose to 300 mg.

Indications

It is allowed to use during pregnancy and lactation. Dosage according to doctor's prescription.

Side effects

Thiamine can cause a number of irritant reactions: itching, hives, Quincke's edema, and sometimes anaphylactic shock can occur. Among the less common effects - tachycardia and sweating.

Contraindications

At the moment, contraindications for use are insignificant. The drug thiamine use instruction prohibits use in cases of hypersensitivity, in women's menopause, with encephalopathy.

Additional Instructions

There are certain recommendations on the use of thiamine. Instructions for use do not recommend the use of the drug as a substitute for dietary nutrition, only with a holistic diet. If ingestion causes rejection of the drug (emetic reflexes, nausea, recently operated), parenteral administration is permitted . If Wernicke's encephalopathy is detected, dextrose should be prescribed before taking the drug.