Cream "Rosex": instructions for use, composition, description, reviews

Why do you need a medical product such as Rosec cream? The answer to this question you will certainly find in the materials of the article. In addition, we will tell you about the pharmacological characteristics of this drug, what is in its composition and how it should be used properly.

Cream "Rosex": composition of the drug and its packaging

Before using this drug, it is necessary to find out what composition it has. According to the attached instructions, this medication includes an active ingredient, such as metronidazole. In addition, this preparation for external use also contains such auxiliary elements as glycerol, benzyl alcohol, non-crystalline sorbitol 70%, isopropyl palmitate, purified water, sodium hydroxide, emulsion wax and lactic acid. Sometimes mistakenly 0.75% cream "Roseks" is taken for ointment. This drug is available for sale in plastic tubes for 15, 5, 50 or 30 g.

In addition to the cream, this product is also available in the form of a gel.

Pharmacological properties of medicament

What is the preparation "Rosex" (cream)? The instruction on the use of the medicine says that it is an excellent anti-acne agent. It should be specially noted that the mechanism of action of this drug is not known precisely. However, experts argue that its active component in the form of metronidazole has increased antioxidant activity.

It has been found that this agent significantly reduces the production of active oxygen by neutrophils, as well as hydrogen peroxide and hydroxyl radicals, which are potential oxidants capable of causing tissue damage at the site of the inflammatory process.

What other properties does the Rosex cream have? The instruction to use this external preparation says that its active ingredient in the form of metronidazole is ineffective against telangiectasias, which are noted in rosacea. Also aerobic microorganisms are stable to this element.

Thus, the medicament in question is an antiprotozoal agent. Experts believe that the principle of its action has a direct connection with the violation of the structure of DNA sensitive to the medium of bacteria.

Pharmacokinetics of the agent

Bioavailability of this drug (oral) is about 80%. After using the medicine, it is quickly distributed in the fluids and tissues of the body. Metronidazole penetrates well through the BBB and the placental barrier.

The connection with plasma proteins is about 20%. Metabolism of the agent passes through the liver by binding to glucuronic acid and oxidation. Drug is taken along with urine (about 60-80%) and feces (about 6-15%).

With local use of the drug (cream, gel), its systemic effect is minimal. The maximum concentration of the active ingredient in the blood serum with external use of the preparation (when applied to the skin of the face) is about 33 ng / ml. It should be noted that this amount of the drug does not exceed 1 percent of the concentration (maximum) of metronidazole in the blood serum after taking the medication (in the form of tablets) orally at 250 mg.

The peak concentration of the active component in the serum after the cutaneous use is observed after about 7-25 hours.

With external application, the concentration of the drug at the site of application is markedly higher than in the blood plasma.

When are they used?

Now you know what the cream "Roseks" is. What is this drug used for? According to the attached instructions, this medication is used for the following abnormalities:

• Acne vulgar;
• Acne pink, including post-steroid;
• Skin diseases of an infectious nature;
• Pressure sores;
• Trophic ulcers;
• Burns;
• Eczema seborrheic;
• eczema;
• Seborrhea is oily;
• Dermatitis seborrheic;
• Wounds creepy;
• Trophic ulcers on the legs (on the background of diabetes mellitus or varicose veins);
• hemorrhoids;
• Pressure sores;
• Cracks in the anus.

These indications refer to the agent for external use (cream, gel). As for oral forms of metronidazole, they are prescribed for the following diseases:

• Giardiasis;
• Urethritis of trichomoniasis in representatives of the stronger sex;
• Urethritis and trichomonas vaginitis in women;
• Dysentery amoeba;
• Combined treatment of severe mixed aerobic and anaerobic infections;
• Anaerobic infections that were caused by metronidazole-sensitive bacteria;
• Prevention of anaerobic infection in surgical interventions (on the urinary tract and abdominal organs).

In what cases is it forbidden to use the cream?

When can not I apply Rosec cream? Contraindications for the use of this product are listed in the attached instructions. According to her, this drug is not allowed to be used with a patient's sensitivity to metronidazole, and during pregnancy (especially in the first trimester) and during lactation.

Methods of using the drug "Rosex" (cream)

For a person, this medication is prescribed only if the patient has acne vulgaris. The drug is applied on a thin layer to pre-cleaned skin. Do this twice a day (before bed and after a morning awakening).

If necessary, the cream "Roseks" is first applied to the gauze dressing, and then applied to the face or to another part of the body. In this form, the local preparation is maintained for half an hour.

Do not wash off the cream with water. It is necessary only to get wet with a paper napkin. Typically, the duration of treatment with this drug is 4-9 weeks. If necessary, the duration of therapy can be increased to 3-4 months, but only according to the recommendations of the attending physician.

It should be especially noted that the gel and cream "Roseks" can be alternated. However, it is recommended to do this at intervals of 8-11 hours.

As practice shows, the therapeutic effect after the application of the drug in question is noted after three weeks.

Are there side effects?

It is not a secret to anyone that almost all medicines (including local and external) have some side effects. And the cream we are considering is not the exception.

According to reviews of patients, after regular use of this tool can contribute to the emergence of various allergic reactions (eg, urticaria and skin rashes). In addition, the cream "Roseks" often causes peeling, flushing, burning of the skin, as well as severe lacrimation.

If you observe at least one of the above-listed side effects, the use of the external remedy should be discontinued and consult a doctor. After the examination, the doctor is obliged to prescribe to the patient a similar, but safer drug.

Effects on intrauterine fetus

Controlled clinical trials on the use of medication during pregnancy and during breastfeeding were not conducted. However, animal studies have shown that the drug for external use does not have a toxic effect on the fetus. In addition, it does not cause pathologies and other malformations. It should also be noted that the cream is not able to penetrate into breast milk.

The use of the drug during pregnancy and during the baby's feeding with breast milk is permissible only if the possible benefit to the mother considerably exceeds the probable risk for the fetus.

Special instructions for the use of external means

What do I need to know before using the external cream "Roseks"? Patients' comments about this drug will be described below.

This medication is for external use only. During use, care should be taken to avoid contact with the mucous membranes. In this regard, do not apply the drug on the face near the eyes. Otherwise, it can cause quite a strong lachrymation.

If the medicine nevertheless got on the mucous membrane of the visual organs, the eyes should immediately be washed with a large volume of warm water.

One can not help saying that it is extremely important to apply a gel or cream "Rosex" to the entire affected area.

The active substance of this drug (metronidazole) is made on a water basis. Moreover, this medicine does not contain fat. In this regard, it is absolutely not noticeable on the face, and also leaves no spots.

Interaction with other means

Can I use this cream for external use together with other drugs? According to experts, with the simultaneous appointment of the cream "Roseks" with the drug "Warfarin" and other indirect anticoagulants, the action of the latter increases, and prothrombin time also increases .

Analogs of the facility and its price

Now you know what the cream "Roseks" is for (the description of the drug was presented above). You can buy this medicine in the amount of 30 g for 450 Russian rubles. If necessary, the external means is replaced by its analogues. Among them, the following medicines are very popular: Aquametro, Arilin, Deflamon, Camezol, Medazol, Metrogil, Metroxan, Metron, Metronidazole, Nidazol, Orvagil "," Rosamet "," Trichobrol "," Trichopol "," Flagil "and so on.

Reviews about the drug

What do patients say about an external agent such as Rosec cream? Reviews about this medicine are only positive. Most patients who used the drug to treat acne, note that after regular use of the cream, they completely got rid of unwanted sores on the face.