The drug "Metoprolol" instructions for use refers to a group of cardioselective beta-blockers that have antiarrhythmic, antihypertensive and antianginal effect. Admission of this drug allows for a relatively short time to slow down AV-conduction, reduce the automatism of the sinus node, excitability and contractility of the myocardium, as well as to reduce heart rate, cardiac output and myocardial oxygen demand. In addition, the cardioselective drug "Metoprolol", the price of which is about fifteen to twenty rubles, effectively suppresses the stimulating effect of catecholamines on the heart for psycho-emotional and physical exertion. As for the basic pharmacokinetic characteristics of this drug, its highest concentration in plasma begins to occur after about one to two hours, and the time of the so-called half-elimination is on average three to seven hours.
The hypotensive preparation "Metoprolol" (the instruction on application is always included) is issued in the form of round tablets of white-cream shade and in the form of a solution intended for subsequent intravenous administration. The composition of this cardioselective drug as an active ingredient is metoprolol tartrate. Tablets additionally contain lactose monohydrate, microcrystalline cellulose, povidone, calcium stearate, talc and crospovidone.
Use the antianginal and antiarrhythmic drug "Metoprolol" instructions for use, provided by the manufacturer, recommends for the treatment of patients who suffer from angina pectoris (including postinfarction), arterial hypertension and arrhythmia (including tachyarrhythmia of the supraventricular type). In addition, quite often doctors prescribe this antihypertensive drug in order to prevent migraine attacks. In the complex treatment of thyrotoxicosis, it is also recommended to begin taking the cardioselective drug Metoprolol. Indications for prescribing include supportive therapy after myocardial infarction. In this case, the treatment regimen in each case is determined exclusively by the doctor on the basis of the analyzes.
As for the list of the main contraindications for the use of this cardioselective medication, here in the first place it should be highlighted the increased sensitivity to tartrate metoprolol, as well as the allergic reaction to any of the auxiliary components. People with heart failure, atrioventricular blockade, pronounced sinus bradycardia, or sinoatrial blockade should likewise not take an antiarrhythmic drug Metoprolol. The instructions for use also do not recommend the prescription of this antihypertensive agent for weakness of the sinus node, disturbances in the peripheral circulation system or arterial hypotension. With great care it is necessary to use this medicine in the presence of hyperthyroidism, diabetes mellitus, bronchial asthma, pheochromocytoma, hypoglycemia, myasthenia gravis, emphysema, psoriasis, metabolic acidosis, non-allergic bronchitis or depression.