Analysis of ACCP in rheumatoid arthritis: norm, decoding

Medical statistics indicate the increase and progression of the number of diseases in the musculoskeletal system. Increasingly, elderly patients complain of pain in their joints. Young people also did not bypass the ailment, children suffer from it. Disease of the joints is important to recognize at the earliest stages to prevent their further progression and other complications. The most common among diseases of the human bone system is rheumatoid arthritis, characterized by a complex course and no less complicated treatment. Therefore, every person suffering from this ailment is obliged to know about the analysis of ACCP in rheumatoid arthritis. Its norm will be given in this article.

What is an ATSCP test?

RA, or rheumatoid arthritis, is a complex pathology of the joints that affects both children and adults. This disease is characterized by inflammation of the synovial membrane, destruction of the cartilaginous tissue of the joint and its deformation. The consequences of the fact that the pathology was not detected at the initial stage and immediate treatment has not been started can be very dangerous. Deformation and destruction of the joint entail a complete or partial loss of motor functions, which in most cases is the path to disability.

What is the purpose of the analysis of ACCP in rheumatoid arthritis? The norm of indicators is of great importance.

What is it for?

An important step is to diagnose rheumatoid arthritis in a timely manner, which will allow to assign effective and correct treatment to a patient who will stop the inflammatory process and restore the function of the joints. For this, 2 methods are used that allow one to determine the concentration of antibodies to the citrulline cyclic peptide (ACPC) and rheumatoid factor (RF).

To diagnose pathology at an early stage, doctors advise the use of an analysis of ATSTs, because this method has more accurate indicators and allows you to determine the disease regardless of the stage. The test for RF is quite specific, and the accuracy of its results mainly depends on the duration of the pathology development.

Rheumatoid arthritis is well revealed in the early period with the aid of the ATSTS test. Also, thanks to him, the amount of antibodies and markers that are circulating in the blood during the progression of the disease is detected in the blood. This test determines the amount of antibodies in the blood relative to the citrulline cyclic peptide. This peptide is an important component of the metabolism. Citrulin is formed during the biochemical reaction with the help of angina, which is a separate amino acid.

That's what ACPI is for rheumatoid arthritis. The norm will be given below.

Attention! It must be said that citrulline does not participate in the synthesis of protein and is excreted within a certain time from the body.

When the joints suffer from arthritis, the body undergoes many changes. At the same time, the structure of the protein amino acid chain, which affects the functionality of the cartilaginous tissue of the joint, is embedded in citrulline. The peptide, which contains citrulline, is perceived by the immune system as being foreign and produces antibodies to eliminate this threat.

What advantages does the analysis of ATSTSP have for rheumatoid arthritis? His norm should be known to everyone.

Advantages of A / CCP

The ACPC test helps to determine only different types of arthritis, including rheumatoid arthritis, but is in no way suitable for diagnosing other diseases. This method of examination of blood serum is one of the most fastidious and at the same time accurate, because it detects not only the disease at its early stage, but also the stage of the disease and its nature. The test is appointed in the diagnosis of rheumatic joint damage and RA at the beginning of its development. The study allows you to make the most complete therapy scheme, which is aimed at getting rid of pain and relieving inflammation, quickly getting rid of a disease like rheumatoid arthritis.

ACPC has a lot of advantages over RF: a high probability of detecting antibodies to ATSPP several months before the development of articular nonspecific syndrome or rheumatoid arthritis in a more complex form of arthritis; The possibility of determining RA at the initial stages of 70%; The possibility of determining the nature of the course of the disease; The possibility of determining RA in the progressive stage in 79% of cases; Specificity and accuracy of the analysis by 98%.

And this all can reveal the analysis of ACCP in rheumatoid arthritis. We have considered what it is.

The method of ATSTSP can be called high-precision, in connection with which the doctors began to appoint it more often to patients who have all the signs of developing arthritis. The results of the test can determine the form of arthritis, as well as predict its course, which allows you to assign the patient the right therapy.

Features of the procedure

What is the preparation procedure for the analysis? After the patient is assigned to the analysis of the ATSPP, he must follow a number of rules. Before the test, you can not eat (for 8 hours). Any liquid, including tea, juice and coffee, can not be consumed within 24 hours. This rule applies to smoking, because the smoker will have to give up the cigarette for 2 hours, until they conduct an analysis of ACCP in rheumatoid arthritis. Decipherment in this case will be more accurate. The peculiarity of the test is precisely its holding on an empty stomach.

Carrying out the test: algorithm

The test is carried out by taking blood from the vein. Then, the serum is extracted from it, which is then used for examination at the ATSP. Serum is recovered in a special centrifuge. Depending on the urgency of the analysis and the employment of the laboratory, the results can be obtained within a week or immediately on the day of the fence.

Important! Serum can be frozen only once, then with repeated freezing, the results will be inaccurate.

How is the ACPC analyzed for rheumatoid arthritis? What it is, we already know.

On the research process: the serum is placed in a test tube and translucent by a laser. This method is called cytofluometry. By scattering the laser beam in the liquid and its character, one can judge the absence or presence of an ATSP in the body.

Cost

The analysis is completely safe and painless for the patient, but quite expensive. The cost of the test varies from a thousand to seven hundred and seven hundred rubles, depending on the urgency and prices of the laboratory that conducts the test. This analysis is not sent to all patients, for this you need to investigate the symptoms of the disease and the patient's complaints.

Next, we will consider how the interpretation of the results of the analysis of ATSCP in rheumatoid arthritis is carried out.

Norm

According to the results of the test, the doctor learns about the presence or absence of RA, the approximate stage of the development of the disease and the severity of its course. It should be noted that this test in medicine is one of the few in which the norm differs little among people of different ages.

After receiving blood, it can be stored for not more than a week at temperatures from to +8 degrees.

Then, an analysis of ACPC in rheumatoid arthritis is performed. -200 degrees is the optimal temperature of freezing the blood sample, after which it can be stored for an unlimited time if necessary.

The norm of analysis in men, women and children of different ages can be designated 3-3.1 U / ml and only in some single cases it can vary slightly: at an early age in a child with an incompletely formed bone system - 2,7-2,7 ED / ml; ACCP in RA of pregnant women - 3.8-4 U / ml; In elderly people, a gradual increase to 2 U / ml is permissible.

How is the analysis deciphered?

Taking into account the results of the analysis, the specialist prescribes complex treatment, the effectiveness of which will be shown later by the repeated test. The correctness of treatment should be judged on the basis of a decrease in the amount of antibody in the serum. Decodes ATSTSP in the presence of rheumatoid arthritis as follows: 0-20 - the indicator is negative; 20,0-39,9 - positive, weakly expressed; 40-59.9 - positive; More than 60 units - positive, strongly pronounced.

Important! Regardless of the fact that 20 U / ml is considered the norm of analysis, many experts are sure that it is possible to exclude RA only in the case when the parameters of the ATSP assay are zero, that is, with complete absence of antibodies in the blood.

Conclusion

It is necessary to remember to each patient that the analysis of ATSTSP is 95% reliable and if the test result was negative, but there are all signs of rheumatoid arthritis, it will be necessary to conduct an additional examination using other diagnostic methods appointed by the attending physician.

We examined the analysis of ACCP in rheumatoid arthritis. In women, in men and in children, the normal indices are somewhat different.