"Nimid" (gel): instructions for use, description of the preparation

The drug "Nimid" in various dosage forms refers to non-steroidal anti-inflammatory drugs with antipyretic analgesia, is used for rheumatic affections of joints and soft tissues. Its main active ingredient is the analgesic nimesulide.

The medication is produced by the Indian company Kusum Heltkhker HTP. Ltd. ".

Variety of the drug

The drug "Nimid" is produced in a solid, liquid and soft dosage form:

• One-component tablets for oral administration;
• Two-component Forte tablets for oral administration;
• Granular powder for oral administration;
• Gel for external use;
• Suspension for oral administration.

Tablets with normal release contain in their composition 100 mg of nimesulide. They are packaged in blisters of 10 pieces, packed in packs of 10, 30 or 100 tablets.

Tablets "Nimid Forte" produced by "New Life" (India) in its composition contain two active components: nimesulide in the amount of 100 mg and tizanidine hydrochloride, equivalent to 2 mg of tizanidine. They are packaged in blisters of 10 pieces and packed in packs # 10. Have a prolonged action.

The drug "Nimid" - granulated powder - is packaged in sachets of 2 g. Each dosage unit contains 100 mg of nimesulide. The medication "Nimid" (granules) is sold for 30 sachets in a pack.

The gel for external application contains 10 mg of nimesulide in 1 g of the preparation. Often this dosage form is mistakenly called so: "Nimid" ointment. Packed gel in tubes of 20, 30 and 100 g, packed in packs.

Suspension for oral administration of 1 ml contains 10 mg of the active ingredient. Produced in vials of 60 ml.

How the drug works

The mechanism of action of the "Nimid" (gel) is associated with the pharmacological features of the active substance. Nimesulide has the ability to anesthetize, reduce temperature and reduce inflammation. It is a non-steroidal anti-inflammatory drug. Its chemical formula does not contain a carboxyl group.

Nimesulide is able to selectively inhibit type 2 cyclooxygenase, to disrupt the synthesis of prostaglandin substances and leukotrienes. The anti-inflammatory effect is associated with inhibition of histamine mast cell secretion, inhibition of the formation of a factor responsible for the activation of platelet cells, the necrosis factor of tumor cells. The medication does not allow the synthesis of bradykinin and cytokine, they cause the pain syndrome, which causes the analgesic effect of the active substance.

The drug "Nimid" (tablets) with prolonged action contains muscle relaxant in the form of tizanidine hydrochloride with a central effect. With his participation, the reflexes of the polysynaptic reflex arc in the spinal cord are inhibited, the tone of the muscles changes. Tizanidine removes an acute painful muscle or chronic spasm, which has a spinal and cerebral origin.

An important feature of the active component of tablets is the ability to reduce the formation of the superoxide of the radical anion damaging the proteins with iron-sulfur clusters. This, in turn, preserves tissues and many enzymes from destruction.

What heals

Means "Nimid" (gel) instruction for use recommends the use for complex therapy of degenerative-inflammatory lesions of the musculoskeletal system. Locally it is used for edema and pain accompanying rheumatic, rheumatoid, psoriatic and gouty arthritis, ankylosing spondylitis, osteoarthritis, Reiter's disease, myalgia, tendonitis, myositis, tendosynovitis.

The drug treats radicular syndrome with osteochondrosis, backache, neuralgia with multiple sclerosis, cerebral palsy, sciatica nerve inflammation, degenerative diseases of the spinal cord. Effective is a gel for the removal of inflammation in soft tissues after trauma associated with rupture and damage of ligaments, bruising and stretching of muscle fibers.

Medication "Nimid" (tablets, granules and suspension) is used to eliminate symptoms of pain in the bones, joints and muscles associated with osteoarthritis, rheumatoid arthritis, bursitis, tendenitis, myalgia.

Analgesic properties of the drug are used in post-traumatic and post-operative pain, gynecological diseases (primary algodismorrhoea, adnexitis), ENT diseases and dental problems, manifested by inflammatory processes and pain syndrome.

Antipyretic effect effectively removes fever in diseases of the upper respiratory system and ENT organs.

Use of tablets

The drug "Nimid Forte" with prolonged action is used not on an empty stomach, but after eating, squeezed with liquid.

Rheumatic diseases, degenerative-dystrophic disorders of the musculoskeletal system and neurological diseases are treated according to this scheme: one tablet in the morning and one in the evening.

To eliminate the pain syndrome in muscle spasms, adults are prescribed a three-time intake of 1 tablet. Dosage and duration of treatment can be changed by the doctor, which depends on the degree of the disease.

The pain syndrome in the inflammatory process or after the operation is eliminated by pills for 5 days. If the effect is insignificant, the selection of another drug is required.

One-component tablets "Nimid" take after breakfast and dinner for 1 pc. Not more than 15 days. It is allowed to use it for children from the age of 12.

Use of suspension

The suspension "Nimid" is drunk after eating. For adults, the daily dose is 100 mg. The maximum dose per day should not exceed 400 mg, it is divided into two doses.

Children after 12 years of the drug in the form of a suspension are given in a daily dosage of 1.5 mg per kg of body weight in two divided doses. The maximum dose for small patients per day should not exceed 5 mg per kg of body weight. The instructions for use indicate that children after 12 years of age with a body weight of more than 40 kg prescribed a dose of 100 mg, divided into two doses. The maximum allowable amount of nimesulide should not exceed 200 mg.

Application of gel

With external use of the "Nimid" (gel), the instruction for use provides for applying to the affected area a column of the drug, whose length is about 3 cm. Then spread the medicine well over the surface of the skin and allow it to dry. For a day, this procedure is carried out 3 to 4 times. The skin of the diseased area should be clean and dry, only in this case it is possible to apply the product.

After the application of the gel "Nimid", the reviews leave the patients mostly positive. It is especially effective with bruises. With its help, painful sensations, swelling of soft tissues are quickly removed, cells of the damaged area are regenerated rapidly, which leads to healing of the sore spot. Many people who suffer frequent injuries, bruises, sprains of ligaments and muscles, the gel "Nimid" is always in the medicine cabinet.

In the complex treatment of rheumatic manifestations, the drug is applied to the area of the patient's joint, which helps to reduce the inflammatory process.

Relatively small price (from 160 to 180 rubles per package) makes the drug "Nimid Gel" affordable for most buyers.

Application of granules

Another form of the drug for oral administration requires preliminary preparation.

Drug "Nimid" (powder) before use instructions for use recommend dilution in warm water. From one sachet poured the granules into a glass with water (200 ml of liquid), mixed to dissolve the medicine. Cook the solution immediately.

For adults and children from 12 years, the drug is prescribed in a dosage of 100 mg, which corresponds to one sachet, 2 times a day after breakfast and dinner. Duration of treatment should not exceed 15 days.

Unwanted consequences

The use of "Nimid" in granules can lead to such adverse reactions:

• To skin rashes, itching, hives, angioedema, rarely - to epidermal necrolysis, Stevens-Johnson syndrome;
• To nausea, pain symptoms in the stomach, constipation, digestive disorders, rarely - peptic ulcer of duodenum and stomach, gastrointestinal bleeding, ulcerous perforations;
• To changes in transaminase activity, rarely - to acute hepatitis;
• To drowsiness, dizziness, headaches;
• To a decrease in the amount of excreted urine, edema, rarely - to insufficient kidney function and allocation of blood in the urine;
• Rarely - to bleeding with thrombocytopenia and increased number of megakaryocytes;
• Rarely - to anaphylactic reactions with bronchospasm, dyspnea.

The use of "Nimid" in tablets and in the form of a suspension can lead to the following side reactions:

• To skin rashes, itching, erythema, increased sweating, dermatitis, rarely - to angioedema, erythema multiforme, facial edema, hives, epidermal necrolysis, Stevens-Johnson syndrome;
• To pain symptoms in the stomach, nausea, constipation, digestive disorders, flatulence, rarely - to a black semi-liquid stool with a bad smell, stomatitis, peptic ulcer of the duodenal ulcer and stomach, bleeding in the digestive tract;
• To cholestasis, jaundice, changes in transaminase activity, rarely - to acute hepatitis;
• To drowsiness, dizziness, headaches, non-inflammatory lesions of the brain;
• To a nervous state, anxiety, nightmarish dreams;
• To urination disorder, edema, blood in the urine, delayed urination, rarely to insufficient kidney function and interstitial nephritis ;
• To an increase in the number of eosinophils, hemoglobin deficiency, rarely to bleeding against thrombocytopenia and increased number of megakaryocytes, hypoplasia of blood cells during hematopoiesis, lack of platelets, bleeding;
• To anaphylactic shock;
• To shortness of breath, rarely to bronchospasm, bronchial asthma;
• To increased pressure, an increase in the frequency of contractions of the heart muscle, rarely - to a sensation of hot flashes, fluctuations in blood pressure;
• To asthenic state, visual impairment, increased potassium in the blood, lower body temperature.
• The undesirable consequences of treatment with the drug "Nimid" (gel), the instruction for use describes such: peeling of the skin, itching, urticaria at the site of application.

In severe cases, which are very rare, there are anaphylactic reactions characterized by vasomotor rhinitis, Quinck's edema, bronchospasm, suffocation.

To whom is contraindicated treatment

Not all people can use the drug "Nimid" in granules, tablets or in the form of a suspension. Contraindications are:

• Peptic ulcer of the duodenum and stomach in acute stage;
• Pronounced violations of the liver, when there is liver failure;
• Hepatotoxic reactions to the drug components in the past;
• Severe disruption of kidney function, when less than 30 ml of creatinine is excreted per minute;
• Simultaneous administration with liver-damaging drugs;
• Possible bleeding;
• Insufficiency of the heart muscle;
• Increased sensitivity to nimesulide and other constituents of the drug;
• pregnancy;
• breast-feeding;
• Children's age till 12 years;
• Chronic alcoholism or drug dependence;
• Fever and influenza;
• Possible surgical pathologies.

Gel "Nimid" is not used when:

• Increased sensitivity to nimesulide and other constituents of the drug;
• When there are dermatitis, infections or skin lesions on the affected area;
• Bronchial asthma from taking acetylsalicylic acid;
• Children under 12 years;
• Pregnancy, in the third trimester.

Analogues

The original preparation based on nimesulide is "Mesulide" produced by the Irish company "Helsin Birex".

The drug "Nimid" analogs has among the generics reproduced on the basis of the original. The main synonyms include such drugs as "Nimesil", "Nimegesic", "Remixid", "Nimesulid", "Naiz", "Nimid Forte".

The manufacturer of "Nimesil" is the company "Laboratory Guidoti SpA" (Italy), although the drug itself is produced in the Spanish company "Laboratorios Menarini SA". The tablet contains active ingredient nimesulide in the amount of 100 mg, which refers to non-steroidal anti-inflammatory drugs from the sulfonanilide class.

An analogue is the Remisid remedy produced by FF Darnitsa. Available in the form of a gel for external use with 10 mg of nimesulide in 1 g of the drug. It is used to treat pathologies of the musculoskeletal system.

The Indian synonym "Nimegesik" of the manufacturer "Alembik Limited" is available in the form of granules for the preparation of a solution or suspension for ingestion, suspension, tablets dispersible, for resorption and soluble in water.

The Russian analogue of the "Nimesulide" medication manufactured by the "Obolenskoe" Pharmaceutical Enterprise CJSC is available in the form of tablets with a dosage of 100 mg of nimesulide. This drug has anti-inflammatory, analgesic and antipyretic effect in various pathological processes of the skeleton and soft tissues of the human body.

The drug "Nyz" produced by the company "Dr. Reddy's Laboratories Ltd" is produced in usual and dispersible tablets, as a suspension for oral administration, in the form of a gel for external use.