Instructions for use - ampicillin

Already for a long time it became known that β-lactamases and their products are the main mechanism for the development of adaptability of various kinds of bacteria to antibiotics. They very effectively contribute to the destruction of the protective rings of antibiotics and practically nullify their therapeutic effect. To overcome this negative effect, practically chemical compounds that deactivate β-lactamases were developed and are primarily clavulanic acid, preparations of sulbactam and tazobactam.

These compounds are included as elements in the so-called inhibitor-protected penicillins - a combination of drugs that include a penicillin antibiotic. Widely known examples of such drugs are ampicillin-sulbactam, amoxicillin, ticarcillin and others making up this group of penicillins. Their use is also effective because they can act as part of a wide variety of cephalosporin combinations of the third generation, while the effectiveness of the active substance remains at a high level.

In the course of various combinations that are used in a number of modern medicines, including antibiotics and β-lactamase inhibitors, the primary activity of penicillins regenerates and they almost completely restore their therapeutic effectiveness against most of the currently known staphylococci, anaerobes and gram-negative Bacteria. In addition, in such drugs, their antimicrobial spectrum is expanding. These include the drug ampicillin / sulbactam, which, depending on the manufacturer, can still be produced under the names Unazin or Sulacillin.

This medicine includes ampicillin and sulbactam, which are present in a 2: 1 ratio. As indicated in the instructions for use, ampicillin and sulbactam in this preparation, in addition to actually blocking β-lactamases, have quite pronounced activity against Neisseria and acinetobacter.

As a rule, the preparation of sultamycillin, which includes sulbactam and ampicillin, is prescribed for internal reception. Tablets on intake are absorbed into the body. Then there is a hydrolysis reaction and a joint action of the ampicillin and sulbactam drug, which provides an increase in the bioavailability of ampicillin even above the level that is achieved by taking an equal dose of traditional ampicillin.

The spectrum of activity of this medicine is also quite wide. Therefore, the most shown application of the drug is for infections of bacterial origin of VDP, sinusitis of various forms and etiology. The medicine is prescribed for diseases of the lower respiratory tract: chronic bronchitis, pneumonia.

According to the instructions for use, ampicillin with a sulbactam content is effective in the treatment of intra-abdominal and various forms of pelvic infections, including infections of soft tissues, bone and joint infectious diseases, sepsis.

The drug ampicillin with sulbactam is much more effective than amoxicillin / clavulanate in the treatment of infections that are initiated by acinetobacter.

The dosage of the drug is determined by the instructions for use. Ampicillin is prescribed inside, for adults the dose is 0.375-0.75 grams, regardless of the intake of food twice a day, if the disease is mild. For heavier forms, taking the drug at 1.5-3.0 grams during the day, if the severity increases, the dose can be increased to 6.0 grams.

Children the drug is prescribed in calculated doses, approximately 50 micrograms per day per one kilogram of the child's weight. Reception is carried out for two times.

Forms of release and reception of the drug details the instructions for use. Ampicillin can also be taken, in addition to tablets, in the form of a powder used to prepare a special suspension (for oral administration). It is also envisaged to use the drug in the form of injections, for this it is produced in the form of a powder. The solvent is applied together with the preparation in one package.