De: instructions for use.

Dosage form

The drug is available in coated tablets cream-pink color. They are biconvex, with an inscription on one side "gbr 152" and a pattern in the form of a square with rounded ends on the other. These are the distinguishing features of the drug de nol. Instructions for use also states that the tablets have little or no aroma or can sometimes have a mild odor of ammonia.

Ingredients: trichalium bismuth dicitrate - 304 mg (1 tab). Excipients - povidol, corn starch, macrogol, potassium polyacrylate, magnesium stearate.

Pharmacological action of the drug

The pharmacological action is associated with the antibacterial action of the drug de nol. The instruction for use states that the effect of the drug is directed to the treatment of ulcers, including those associated with Helicobacter pylori, and also has a significant astringent and anti-inflammatory effect. The preparation forms an insoluble substance in the acid medium of the stomach, bismuth oxychloride, and also forms chelate compounds with the protein substrate, which manifest themselves as a film lying on the surface of ulcers and erosions.

Indications for use , instructions for use

• Ulcerative disease of the duodenum and stomach (and in the phase of exacerbation, too).

• Chronic gastroduodenitis and gastritis, in the acute phase, including.

• Irritable bowel syndrome, which occurs with diarrhea.

• Functional dyspepsia, which has nothing to do with organic gastrointestinal diseases.

Side effects

The use of de-nol can cause a number of side effects from various body systems.

Side effects related to the digestive system: vomiting, nausea, diarrhea, constipation. All the side effects related to the gastrointestinal tract are transitory in nature and can pass even before the drug is discontinued.

Side effects in the form of a dermatological reaction - itching and skin rash.

The side effect related to the CNS is encephalopathy, which occurs only with prolonged use of the drug due to the accumulation of bismuth.

Contraindications

Contraindications to the drug de nologic instructions for use contains a reduced form. The use of the drug should be started only after consultation with the doctor. In the instruction there are instructions on prohibition of reception at pregnancy and a lactemia, hypersensibility to components, infringement of function of kidneys.

Overdose

In order for side effects to not manifest themselves, the drug should not be taken more than 8 weeks, since in the central nervous system can accumulate bismuth, which leads to encephalopathy.

Do not disrupt the recommended daily intake for children and adults, so that the drug does not show toxic effects.

During the course of taking the drug, the patient's stool can be dyed black. In this there is nothing terrible, because the stool is colored due to the removal of bismuth sulphide from the body. In addition, the language of the patient taking the drug, can change its color: slightly darkened.

With prolonged use of the drug in the event that doses exceed the recommended, it is possible to impair renal function. It must be said that such violations are completely reversible in the event that the use of the drug is canceled.

If the kidney function is slightly disturbed, the patient needs to take saline laxatives and activated charcoal, and then perform symptomatic therapy. If the disorder is caused by a high content of bismuth in the blood, then it is necessary to introduce complexing agents into the bloodstream, which neutralize its effect. In especially severe cases of renal failure, hemodialysis is necessary.

Drug Interactions

It is not recommended to use the drug in the event that simultaneously with it other preparations containing bismuth are taken.

Doctors do not advise taking deox at the same time as food, liquids and other medicines. It is better to do this, at least for half an hour before or after eating. Otherwise, the efficiency of the deletions can be significantly reduced.